51643-31-3

Upstream product

• 6575-13-9 2,6-dimethylbenzonitrile 

Downstream Products

• 53514-90-2 [2-(2,6-dimethyl-phenyl)-4-phenyl-thiazol-5-yl]-acetic acid 
• 1554665-61-0 ethyl 2-(2,6-dimethylphenyl)thiazole-4-carboxylate 
• 1620790-12-6 ethyl 4-(2,6-dimethylphenyl)thiazole-2-carboxylate 
• 4115-18-8 3,5-bis-(4-methoxyphenyl)-[1,2,4]thiadiazole 

Relevant academic research and scientific papers

Aerobic Visible-Light Induced Intermolecular S?N Bond Construction: Synthesis of 1,2,4-Thiadiazoles from Thioamides under Photosensitizer-Free Conditions

Aerobic visible-light induced intermolecular S?N bond construction has been achieved without the addition of photosensitizer, metal, or base. With this strategy, 1,2,4-thiadiazoles can be obtained from thioamides. Preliminary mechanistic investigation suggested that the excited state of thioamides undergoes a single-electron-transfer (SET) process to afford thioamidyl radicals, which can be further transformed into a 1,2,4-thiadiazole through desulfurization and oxidative cyclization. The reaction has good functional group tolerance and represents a green method for the construction of S?N bonds.