516471-66-2

Upstream product

• 516471-64-0 (3-chloro-propyl)-(1-cyclohexylmethyl-piperidin-4-yl)-carbamic acid tert-butyl ester 
• 24424-99-5 di-tert-butyl dicarbonate 
• 64306-77-0 1-cyclohexa-1',4'-dienylmethyl-4-aminopiperidine 

Downstream Products

• 591228-77-2 [3-(4-benzyloxy-benzenesulfonylamino)-propyl]-(1-cyclohexylmethyl-piperidin-4-yl)-carbamic acid tert-butyl ester 
• 328039-93-6 4-benzyloxy-N-[3-(1-cyclohexylmethyl-piperidin-4-ylamino)-propyl]-3,5-dimethoxy-benzamide 

Relevant academic research and scientific papers

Novel and potent anti-malarial agents

Readily accessible, novel, and potent anti-malarial compounds have been developed. Optimization of the initial lead structure resulted in derivatives with IC50 values from 7 to 35 nM against chloroquine-sensitive and 70-350 nM against chloroquine-resistant strains of Plasmodium falciparum.