516482-54-5

Upstream product

• 39136-63-5 5-phenyl-1,3-thiazol-2-amine 
• 1629144-44-0 2-phenoxy-5-phenylthiazole 
• 329794-40-3 2-chloro-5-phenyl-thiazole 

Downstream Products

• 1086332-18-4 quinolin-6-yl-acetic acid N'-(5-phenyl-thiazol-2-yl)-hydrazide 
• 1086331-43-2 6-phenyl-thiazolo[2,3-c][1,2,4]triazole-3-thiol 
• 1629144-90-6 2-(2-(4-bromobenzylidene)hydrazinyl)-5-phenylthiazole 
• 1629145-10-3 2-(2-(4-methoxybenzylidene)hydrazinyl)-5-phenylthiazole 
• 324578-44-1 phenyl-acetic acid N'-(4-phenyl-thiazol-2-yl)-hydrazide 

Relevant academic research and scientific papers

CALPAIN MODULATORS AND THERAPEUTIC USES THEREOF

Disclosed herein are small molecule calpain modulator compositions, pharmaceutical compositions, the use and preparation thereof.

2,4- and 2,5-disubstituted arylthiazoles: Rapid synthesis by C-H coupling and biological evaluation

Life-threatening infections caused by bacteria that have developed resistance to common antibiotics, such as methicillin-resistant Staphylococcus aureus (MRSA), have become a serious problem in hospitals and other areas all over the world. Thus, the development of an effective class of antibiotics against these bacteria is an urgent subject. Herein, we report a step-economical and diversity-oriented synthesis of a series of 2-arylidenehydrazinyl-4- arylthiazole and 2-arylidenehydrazinyl-5-arylthiazole analogues that utilizes C-H coupling methodologies. A library of 54 new congeners were synthesized and tested for their biological potential. Moreover, new knowledge regarding the structure-activity relationships (SARs) of these heterobiaryl compounds was collected. Copyright

HETEROCYCLIC KINASE MODULATORS

The present disclosure provides heterocyclic protein kinase modulators and methods of using these compounds to treat diseases mediated by kinase activity.