5165-45-7

Basic information

• Product Name: 1H-Indole-3-carboxylic acid, 5-hydroxy-2-methyl-1-(4-methylphenyl)-, ethyl ester
• CAS NO: 5165-45-7
• Molecular Formula: C19H19NO3
• Molecular Weight: 309.365
• Mol File: 5165-45-7.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 1H-Indole-3-carboxylic acid, 5-hydroxy-2-methyl-1-(4-methylphenyl)-, ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Indole-3-carboxylic acid, 5-hydroxy-2-methyl-1-(4-methylphenyl)-, ethyl ester(5165-45-7)
• EPA Substance Registry System: 1H-Indole-3-carboxylic acid, 5-hydroxy-2-methyl-1-(4-methylphenyl)-, ethyl ester(5165-45-7)

Safety Data

• Hazardous Substances Data: 5165-45-7(Hazardous Substances Data)

Usage

Chemical class

Indole derivatives

Structure

1H-Indole-3-carboxylic acid, 5-hydroxy-2-methyl-1-(4-methylphenyl)-, ethyl ester

Type

Ethyl ester derivative

Biological activities

Antioxidant and anti-inflammatory properties

Therapeutic potential

Potential therapeutic agent for various diseases, including cancer and neurological disorders.

Upstream product

• 141-97-9 ethyl acetoacetate 
• 106-49-0 p-toluidine 
• 7598-91-6 ethyl 5-hydroxy-2-methylindole-3-carboxylate 
• 624-31-7 4-tolyl iodide 
• 51071-20-6 Ethyl N-p-tolyl-β-aminocrotonate 
• 106-51-4 p-benzoquinone 

Downstream Products

• 134826-48-5 1-(p-tolyl)-2-methyl-3-ethoxycarbonyl-5-(3-cyanopyridyl-2-oxy)indole 
• 915718-38-6 1-p-tolyl-5-methoxy-3-(N-phenyl-thiosemicarbazinocarbonyl)-2-methylindole 
• 915718-35-3 1-p-tolyl-5-methoxy-3-(N-allyl-thiosemicarbazinocarbonyl)-2-methylindole 
• 915718-23-9 1-p-tolyl-3-hydrazinocarbonyl-5-methoxy-2-methylindole 
• 19616-06-9 5-methoxy-2-methyl-1-p-tolyl-indole-3-carboxylic acid ethyl ester 
• 134826-59-8 5-(3,5-Dicyano-4-phenylamino-pyridin-2-yloxy)-2-methyl-1-p-tolyl-1H-indole-3-carboxylic acid ethyl ester 
• 134826-51-0 5-(3-Cyano-4-phenylamino-pyridin-2-yloxy)-2-methyl-1-p-tolyl-1H-indole-3-carboxylic acid ethyl ester 
• 134826-54-3 5-[3-Cyano-4-(4-methoxy-phenylamino)-pyridin-2-yloxy]-2-methyl-1-p-tolyl-1H-indole-3-carboxylic acid ethyl ester 
• 134826-57-6 5-(3-Cyano-4-p-tolylamino-pyridin-2-yloxy)-2-methyl-1-p-tolyl-1H-indole-3-carboxylic acid ethyl ester 

Relevant articles and documents

α-d-Galacturonic Acid as Natural Ligand for Selective Copper-Catalyzed N-Arylation of N-Containing Heterocycles

The first application of α-d-galacturonic acid hydrate (GalA) is reported here, as a potential O-donor ligand. The C-N couplings of N-heterocycles with aryl halides or arylboronic acids could be readily conducted and exhibited good functional group tolerance with characters of selectivity. These N-Arylazoles allow rapid access to several pharmaceutical intermediates and can be easily transformed into a variety of other interesting scaffolds as well.