5165-45-7

Usage

Chemical class

Indole derivatives

Structure

1H-Indole-3-carboxylic acid, 5-hydroxy-2-methyl-1-(4-methylphenyl)-, ethyl ester

Type

Ethyl ester derivative

Biological activities

Antioxidant and anti-inflammatory properties

Therapeutic potential

Potential therapeutic agent for various diseases, including cancer and neurological disorders.

Upstream product

• 51071-20-6 Ethyl N-p-tolyl-β-aminocrotonate 
• 106-51-4 p-benzoquinone 
• 7598-91-6 ethyl 5-hydroxy-2-methylindole-3-carboxylate 
• 624-31-7 4-tolyl iodide 
• 106-49-0 p-toluidine 
• 141-97-9 ethyl acetoacetate 

Downstream Products

• 915718-38-6 1-p-tolyl-5-methoxy-3-(N-phenyl-thiosemicarbazinocarbonyl)-2-methylindole 
• 915718-35-3 1-p-tolyl-5-methoxy-3-(N-allyl-thiosemicarbazinocarbonyl)-2-methylindole 
• 915718-23-9 1-p-tolyl-3-hydrazinocarbonyl-5-methoxy-2-methylindole 
• 19616-06-9 5-methoxy-2-methyl-1-p-tolyl-indole-3-carboxylic acid ethyl ester 
• 134826-54-3 5-[3-Cyano-4-(4-methoxy-phenylamino)-pyridin-2-yloxy]-2-methyl-1-p-tolyl-1H-indole-3-carboxylic acid ethyl ester 
• 134826-57-6 5-(3-Cyano-4-p-tolylamino-pyridin-2-yloxy)-2-methyl-1-p-tolyl-1H-indole-3-carboxylic acid ethyl ester 
• 134826-48-5 1-(p-tolyl)-2-methyl-3-ethoxycarbonyl-5-(3-cyanopyridyl-2-oxy)indole 
• 134826-51-0 5-(3-Cyano-4-phenylamino-pyridin-2-yloxy)-2-methyl-1-p-tolyl-1H-indole-3-carboxylic acid ethyl ester 
• 134826-59-8 5-(3,5-Dicyano-4-phenylamino-pyridin-2-yloxy)-2-methyl-1-p-tolyl-1H-indole-3-carboxylic acid ethyl ester 

Relevant academic research and scientific papers

α-d-Galacturonic Acid as Natural Ligand for Selective Copper-Catalyzed N-Arylation of N-Containing Heterocycles

The first application of α-d-galacturonic acid hydrate (GalA) is reported here, as a potential O-donor ligand. The C-N couplings of N-heterocycles with aryl halides or arylboronic acids could be readily conducted and exhibited good functional group tolerance with characters of selectivity. These N-Arylazoles allow rapid access to several pharmaceutical intermediates and can be easily transformed into a variety of other interesting scaffolds as well.

Synthesis and biological screening of some new novel indole derivatives

Synthesis of some novel indole derivatives has been undertaken by the reaction of 1,4-benzoquinone with ethyl-β-(arylamino)-crotonates in the presence/absence of nitrogen atmosphere. The products 1a-o have been screened for their antimicrobial activity an