516508-80-8 Usage
Uses
3’-Hydroxy-amiodarone Hydrochloride is a metabolite of the drug Amiodarone Hydrochloride (A632950), which is a non-selective ion channel blocker. Antiarrhythmic (class III).Also, it is derived from 4-Pentyn-1-ol (P227540), which is an alkyne alcohol that is used as an initiator in ring-opening polymerization reactions. 4-Pentyn-1-ol is capable of undergoing cyclosisomerization, and is also used as a reactant in the synthesis of (+)-Serinolamide A, a cannabinoid CB1 receptor agonist.
Check Digit Verification of cas no
The CAS Registry Mumber 516508-80-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 5,1,6,5,0 and 8 respectively; the second part has 2 digits, 8 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 516508-80:
(8*5)+(7*1)+(6*6)+(5*5)+(4*0)+(3*8)+(2*8)+(1*0)=148
148 % 10 = 8
So 516508-80-8 is a valid CAS Registry Number.
516508-80-8Relevant articles and documents
Identifying a selective substrate and inhibitor pair for the evaluation of CYP2J2 activity
Lee, Caroline A.,Jones III,Katayama, Jonathan,Kaspera, Ruediger,Jiang, Ying,Freiwald, Sascha,Smith, Evan,Walker, Gregory S.,Totah, Rheem A.
, p. 943 - 951 (2012)
CYP2J2, an arachidonic acid epoxygenase, is recognized for its role in the first-pass metabolism of astemizole and ebastine. To fully assess the role of CYP2J2 in drug metabolism, a selective substrate and potent specific chemical inhibitor are essential.
