516517-93-4Relevant academic research and scientific papers
Highly stereoselective generation of complex oxy -bicyclic scaffolds via an atom-economic Pd(II)-catalyzed hydroalkynylation, isomerization and diels-alder cycloaddition sequence
Shen, Ruwei,Chen, Ke,Deng, Qiulin,Yang, Jianjun,Zhang, Lixiong
supporting information, p. 1208 - 1211 (2014/03/21)
An atom-economic tandem Pd(II)-catalyzed hydroalkynylation, alkyne-allene isomerization, and Diels-Alder cycloaddition is reported. The reaction employs readily available starting substrates, proceeds in a highly ordered fashion, features high regio- and
A concomitant allylic azide rearrangement/intramolecular azide-alkyne cycloaddition sequence
Vekariya, Rakesh H.,Liu, Ruzhang,Aube, Jeffrey
supporting information, p. 1844 - 1847 (2014/05/06)
An intramolecular Huisgen cycloaddition of an interconverting set of isomeric allylic azides with alkynes affords substituted triazoles in high yield. The stereoisomeric vinyl-substituted triazoloxazines formed depend on the rate of cycloaddition of the d
New indium-mediated cyclisation reactions of tethered haloenynes in aqueous solvent systems
Goeta, Andres,Salter, Matthew M.,Shah, Hummad
, p. 3582 - 3599 (2007/10/03)
The intramolecular cyclisation of tethered allyl bromides onto terminal alkynes mediated by metallic indium proceeds smoothly and cleanly in mixtures of THF and H2O to give unsaturated carbocycles and heterocycles in good yield. Alternatively, the cyclisation may be carried out in anhydrous THF with the aid of acid catalysis. The reaction is also mediated by a range of indium salts and proceeds with substoichiometric quantities of indium in the presence of a co-reductant. Deuteration studies show that the reaction proceeds via a concerted syn carboindination of the carbon-carbon triple bond to give an intermediate, which is protonated in situ.
