516526-33-3

Upstream product

• 516526-32-2 4-(7-benzyloxy-6-methoxyquinolin-4-yloxy)aniline 
• 123324-71-0 p-tert-butylphenylboronic acid 

Downstream Products

• 516522-69-3 (4-Tert-butylphenyl)-{4-[7-(3-chloropropoxy)-6-methoxy-4-quinolyloxy]phenyl}amine 
• 516522-68-2 (4-tert-butylphenyl)-{4-[7-(2-chloroethoxy)-6-methoxyquinolin-4-yloxy]pheny}amine 
• 516522-67-1 4-[4-(4-Tert-butylphenylamino)phenoxy]-6-methoxyquinolin-7-ol 

Relevant academic research and scientific papers

QUINOLINE OR QUINAZOLINE DERIVATIVES INHIBITING AUTO-PHOSPHORYLATION OF FIBROBLAST GROWTH FACTOR RECEPTORS

An objective of the present invention is to provide novel compounds which have inhibitory activity against autophosphorylation of an FGF receptor family and, when orally or intraveneously administered, can suppress the growth of cancer cells. The compounds of the present invention are represented by formula (I) or a pharmaceutically acceptable salt or solvate thereof: wherein X represents CH or N; Z represents 0 or S; Q represents NR10, CR11R12, carbonyl, O, S(=O)m, wherein m is 0 to 2, or urea; R1 to R3 each independently represent H, OH, halogen, nitro, amino, alkyl, alkoxy or the like in which the alkyl and alkoxy groups are optionally substituted; R4 represents H; R5 to R8 each independently represent H, halogen, alkyl, or alkoxy; and R9 represents an optionally substituted carbocyclic or heterocyclic group.