51660-08-3

Usage

Uses

Used in Pharmaceutical Industry:
5-CHLORO-2-METHYL-6-PHENYL-2,3-DIHYDROPYRIDAZIN-3-ONE is used as a chemical intermediate for the synthesis of various pharmaceutical compounds. Its unique structure allows it to be a key component in the development of new drugs with potential therapeutic applications.
Used in Chemical Industry:
In the chemical industry, 5-CHLORO-2-METHYL-6-PHENYL-2,3-DIHYDROPYRIDAZIN-3-ONE serves as a building block for the creation of other complex organic molecules. Its versatility in chemical reactions makes it valuable for the synthesis of specialty chemicals and materials with specific properties for various applications.

InChI:InChI=1/C10H7ClN2O/c11-8-6-9(14)12-13-10(8)7-4-2-1-3-5-7/h1-6H,(H,12,14)

Upstream product

• 71-43-2 benzene 

Downstream Products

• 33389-38-7 5-chloro-2-methyl-6-phenylpyridazin-3(2H)-one 
• 1204665-41-7 5-chloro-2-(4-methoxybenzyl)-6-phenylpyridazin-3(2H)-one 
• 1204665-46-2 5-methoxy-2-(4-methoxybenzyl)pyridazin-3(2H)-one 
• 126337-04-0 5-azido-6-phenyl-3(2H)-pyridazinone 
• 87769-63-9 5-amino-6-phenyl-1,6-dihydropyridazin-3(2H)-one 
• 1610354-27-2 1-((3S,4R)-4-(3,4-difluorophenyl)-1-(2-methoxyethyl)pyrrolidin-3-yl)-3-(6-oxo-3-phenyl-1-(2,2,2-trifluoroethyl)-1,6-dihydropyridazin-4-yl)urea 
• 1610354-61-4 5-amino-6-phenyl-2-(2,2,2-trifluoroethyl)pyridazin-3(2H)-one 
• 1610354-60-3 5-azido-6-phenyl-2-(2,2,2-trifluoroethyl)pyridazin-3(2H)-one 
• 1206156-58-2 2-(4-nitrobenzyl)-5-chloro-6-phenylpyridazin-3(2H)-one 
• 1206156-62-8 2-(4-iodobenzyl)-5-chloro-6-phenylpyridazin-3(2H)-one 
• 1206156-57-1 2-(2-nitrobenzyl)-5-chloro-6-phenylpyridazin-3(2H)-one 
• 1206156-63-9 2-(2-methoxybenzyl)-5-chloro-6-phenylpyridazin-3(2H)-one 
• 1206156-61-7 2-(2-iodobenzyl)-5-chloro-6-phenylpyridazin-3(2H)-one 
• 1206156-60-6 2-(2-fluorobenzyl)-5-chloro-6-phenylpyridazin-3(2H)-one 

Relevant academic research and scientific papers

Ureido-Pyridazinone Derivatives: Insights into the Structural and Conformational Properties for STAT3 Inhibition

Three new ureido-pyridazinone derivatives, which are structurally related to the known STAT3 inhibitor AVS-0288, were designed by taking into account the structure-activity relationships determined for several ureido-oxadiazole derivatives previously studied by our group. Their synthesis was first attempted through suitable 5-aminopyridazinone intermediates (6a and 6b), which molecular structures were confirmed by means of X-ray diffraction data on 6a. Amine functionalization was unsuccessful, therefore, an alternative method was devised. Dual-luciferase and AlphaScreen-based assays were used to test their activity. The obtained data were rationalized on the basis of a modeling study, which focused our attention on the geometrical preferences of the ureido moiety. Computational results seem to indicate that both the 1,2,5-oxadiazole ring and the extended ZZ arrangement are essential and probably act in a synergistic way to confer significant activity against STAT3.

PYRROLIDINYL UREA, THIOUREA, GUANIDINE AND CYANOGUANIDINE COMPOUNDS AS TRKA KINASE INHIBITORS

Compounds of Formula (I): or stereoisomers, tautomers, or pharmaceutically acceptable salts, or solvates or prodrugs thereof, where R1, R2, Ra, Rb, Rc, Rd, X, Ring B, and Ring C are as defined herein, and wherein Ring B moiety and the NH-C(=X)-NH moiety are in the trans configuration, are inhibitors of TrkA kinase and are useful in the treatment of diseases which can be treated with a TrkA kinase inhibitor such as pain, cancer, inflammation/inflammatory diseases, neurodegenerative diseases, certain infectious diseases, Sjogren's syndrome, endometriosis, diabetic peripheral neuropathy, prostatitis and pelvic pain syndrome.

Pyridazines. XV. Synthesis of 6-aryl-5-amino-3(2H)-pyridazinones as potential platelet aggregation inhibitors

Several 3(2H)-pyridazinones with amino groups at the 5-position of the pyridazine nucleus have been prepared. The 6-aryl-5-halo-3(2H)-pyridazinones obtained from mucochloric and mucobromic acid lead to the corresponding 5- alkylamino-3(2H)-pyridazinones,

PYRIDAZINE DERIVATIVES, IX. SYNTHESIS OF 2H-PYRIDAZIN-3-ONES WITH AROYLPIPERAZINYL GROUPS

Several 2H-pyridazin-3-ones with phenyl- or 2-furoylpiperazinyl group, have been prepared. 6-Phenyl-5-(N4-aroyl-N1-piperazinyl)-2H-pyridazin-3-ones were obtained by nucleophilic substitution of the chlorine atom of 6-phenyl-5-chloro-