51679-05-1Relevant academic research and scientific papers
Substituted 2-(R)-Methyl piperazines as muscarinic M2 selective ligands
Kozlowski, Joseph A,Zhou, Guowei,Tagat, Jayaram R.,Lin, Sue-Ing,McCombie, Stuart W.,Ruperto, Vilma B.,Duffy, Ruth A.,McQuade, Robert A.,Crosby Jr., Gordon,Taylor, Lisa A.,Billard, William,Binch III, Herbert,Lachowicz, Jean E.
, p. 791 - 794 (2007/10/03)
A novel series of 2-(R)-methyl-substituted piperazines (e.g., 2) is described. They are potent M2 selective ligands that have > 100-fold selectivity versus the M1 receptor. In the rat microdialysis assay, compound 14 showed significantly enchanced levels of acetylcholine after oral administration.
