51687-14-0

Basic information

• Product Name: 4-(6-nitroquinazolin-4-ylamino)benzoic acid
• CAS NO: 51687-14-0
• Molecular Weight: 310.269
• Mol File: 51687-14-0.mol

Chemical Properties

• CAS DataBase Reference: 4-(6-nitroquinazolin-4-ylamino)benzoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(6-nitroquinazolin-4-ylamino)benzoic acid(51687-14-0)
• EPA Substance Registry System: 4-(6-nitroquinazolin-4-ylamino)benzoic acid(51687-14-0)

Safety Data

• Hazardous Substances Data: 51687-14-0(Hazardous Substances Data)

Upstream product

• 150-13-0 4-amino-benzoic acid 
• 17420-30-3 5-nitroanthranilonitrile 
• 39263-34-8 N′-(2-cyano-4-nitrophenyl)-N,N-dimethylformimidamide 

Relevant articles and documents

Exploring MDR-TB Inhibitory Potential of 4-Aminoquinazolines as Mycobacterium tuberculosis N-Acetylglucosamine-1-Phosphate Uridyltransferase (GlmUMTB) Inhibitors

Drug resistance tuberculosis is one of the challenging tasks that dictates the desperate need for the development of new antitubercular agents which operate via novel modes of action. Here, we are reporting on 4-aminoquinazolines as M. tuberculosis N-acetylglucosamine-1-phosphate uridyltransferase (GlmUMTB) inhibitors to overcome the problem of the MDR-TB. Amongst the synthesized compounds, two of them were observed to be the effective compounds of the series (IC50=6.4 μM (H37Rv), MIC=25 μM (MDR-TB) and IC50=2.9 μM (H37Rv), MIC=6.25 μM (MDR-TB), respectively).

4-AMINOQUINAZOLINE DERIVATIVES AND USES THEREOF

The present invention provides a 4-aminoquinazoline derivative having the chemical structure of the following formula, and the use thereof. It is demonstrated by the pharmacological experiment that, the compound or a salt thereof according to the present

4-Aminoquinazoline Derivatives and Uses Thereof

The present invention provides a 4-aminoquinazoline derivative having the chemical structure of the following formula, and the use thereof. It is demonstrated by the pharmacological experiment that, the compound or a salt thereof according to the present

COMPOSITIONS AND METHODS FOR MODULATING GATED ION CHANNELS

Disclosed are quinoline and quinazoline compounds which modulate the activity of the gated ion channels. Compounds that modulate these gated ion channels are useful in the treatment of diseases and disorders related to pain, inflammation, the neurological system, the gastrointestinal system and genitourinary system. Preferred compounds include quinoline or quinazoline derivatives substituted at the 4- position via N(H), C(O) or O moieties.