51687-73-1Relevant academic research and scientific papers
Analogues of σ receptor ligand 1-cyclohexyl-4-[3-(5-methoxy-1,2,3,4- tetrahydronaphthalen-1-yl)propyl]piperazine (PB28) with added polar functionality and reduced lipophilicity for potential use as positron emission tomography radiotracers
Abate, Carmen,Niso, Mauro,Lacivita, Enza,Mosier, Philip D.,Toscano, Annamaria,Perrone, Roberto
supporting information; experimental part, p. 1022 - 1032 (2011/04/26)
1-Cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl] piperazine 1 (PB28) represents an excellent lead candidate for therapeutic and/or diagnostic applications in oncology. However, because its utility is limited by its relatively high de
CHEMISTRY OF 1,8-SUBSTITUTED NAPHTHALENES. XVII. SYNTHESIS AND HETEROCYCLIZATION OF peri-ACETYLAMINO-SUBSTITUTED NAPHTHALDEHYDES
Mezheritskii, V. V.,Minyaeva, L. G.
, p. 2150 - 2153 (2007/10/02)
The Rieche formylation of 1-acetylamino- and 1-(N-acetyl-N-methylamino)-5-methoxynaphthalenes gives their 8-formyl-substituted derivatives.The products were the first representatives of peri-acetylamino-substituted naphthaldehydes which undergo heterocyclization under the influence of perchloric acid to the previously unknown benzoindolium cations not containing substituents at position 2 of the peri-heterocyclic ring.The reaction of 1-(N-acetyl-N-methylamino)-5-methoxy-8-formylnaphthalene with the Vilsmeier complex gave 1-methyl-3-formyl-7-methoxynaphthoazepin-2-one, which is the first rep resentative of the new peri-heterocyclic system naphthoazepine.
