51693-88-0Relevant academic research and scientific papers
Preparation process of fluorine substituted aromatic compound
-
, (2008/06/13)
A preparation process of a fluorine substituted aromatic compound comprising reacting an alkali metal or alkali earth metal salt of an aromatic compound having a hydroxy group with an organic fluorinating agent is disclosed. As a representative fluorinating agent, a bis-dialkylamino-difluoromethane compound, for example, 2,2′-difluoro-1,3-dimethylimidazolidine, is exemplified. According to the process, an industrially useful fluorinated aromatic compound, for example, a fluorobenzene, a fluorine substituted benzophenone, a fluorine substituted diarylsulfone can be prepared with ease in economy without specific equipment.
SUBSTITUTED CYCLOALKYLAMINE DERIVATIVES AND THEIR USE AS CALCIUM CHANNEL ANTAGONISTS
-
, (2008/06/13)
A method of treatment of a condition or disease related to the accumulation of calcium in the brain cells of a mammal which comprises administering to a subject in need thereof an effective amount of a compound of formula (I), wherein X is O, S, C=O or a bond; p and q are independently 0-4; R. sup.1 and R 2 are each independently selected from the group consisting of hydrogen, C 1-6 alkyl, C 3-6 cycloalkyl or C 3-6 cycloalkylC 1-4 alkyl; n is 1, 2, 3 or 4; and Ar is phenyl optionally substituted by 1 to 3 substituents selected from; halo, C 1-4 alkyl, C 1-4 alkoxy, C 1-2 alkylenedioxy, trifluoromethyl, trifluoromethoxy, CN, NO 2, amino, mono-or di-alkylamino and Ph(Alk 1) r Y(Alk 2) s--where Ph is optionally substituted phenyl, Y is a bond, oxygen or a carbonyl group, Alk 1 and Alk 2 are independently C. sub.1-4 alkyl which may be straight or branched and r and s are independently 0 or 1, provided that the length of (Alk 1) r Y(Alk 2) s does not exceed 5 atoms, and pharmaceutically acceptable salts thereof; in the manufacture of a medicament for the treatment of a disorder wherein a calcium channel antagonist is indicated, e.g. ischaemic stroke. Certain novel compounds within formula (I) are also claimed.
