5170-49-0 Usage
Usage
Pain medication and anesthesia Fentanyl is used as a powerful analgesic (pain reliever) and anesthetic in medical settings.
Potency
50 to 100 times more potent than morphine Fentanyl is a highly potent opioid, making it much stronger than morphine in terms of pain relief and other effects.
Mechanism of action
Binds to the body's opioid receptors Fentanyl works by attaching to specific receptors in the body, which are involved in pain perception, sedation, and feelings of euphoria.
Risks
High risk of overdose and potential for abuse and addiction Due to its potency and addictive nature, fentanyl carries a significant risk of overdose and addiction, especially when used illicitly or without proper medical supervision.
Public health concern
Widespread abuse and addiction Fentanyl's potent nature and high potential for abuse have made it a major public health issue, with many individuals becoming addicted to the drug and seeking it outside of medical settings.
Check Digit Verification of cas no
The CAS Registry Mumber 5170-49-0 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 5,1,7 and 0 respectively; the second part has 2 digits, 4 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 5170-49:
(6*5)+(5*1)+(4*7)+(3*0)+(2*4)+(1*9)=80
80 % 10 = 0
So 5170-49-0 is a valid CAS Registry Number.
5170-49-0Relevant academic research and scientific papers
Studies on propafenone-type modulators of multidrug resistance VI. Synthesis and pharmacological activity of compounds with varied spacer length between the central aromatic ring and the nitrogen atom
Chiba, Peter,Annibali, Danilo,Hitzler, Manuela,Richter, Elisabeth,Ecker, Gerhard
, p. 357 - 364 (2007/10/03)
A series of propafenone-type modulators of multidrug resistance (MDR) with varied spacer length between the central aromatic ring and the positively chargeable nitrogen atom was synthesized and tested for their ability to block P-glycoprotein-mediated transport of daunomycin out of tumor cells. Synthesis was achieved by O-alkylation of o-hydroxy-3- phenylpropiophenone with dibromoalkanes and subsequent nucleophilic substitution of the bromine with piperidine. All compounds showed high MDR- modulating activity with EC50 values from 1.450.15 μM. Generally, activity increased with increasing number of methylene groups, whereby it reaches a plateau for compounds with more than five methylene groups between the ether oxygen and the nitrogen atom.
