51707-39-2

Usage

Type

Chemical compound

Appearance

White to off-white crystalline powder

Solubility

Soluble in organic solvents such as dimethyl sulfoxide and dimethylformamide

Usage

Reagent in organic synthesis

Application

Precursor in the production of dyes and pigments

Application

Corrosion inhibitor in the petroleum industry

Use

Synthesis of various pharmaceutical compounds

Potential use

Anti-cancer agent

Potential use

Anti-inflammatory agent

Potential therapeutic applications

Inhibition of cancer cell growth and reduction of inflammation

Note

Further research is necessary to fully understand the therapeutic applications of 2-AMINO-4-CHLOROBENZENE-1-CARBOHYDRAZIDE (ACC).

Upstream product

• 5900-58-3 2-amino-4-chloro-benzoic acid methyl ester 
• 40928-13-0 4-chloroisatoic anhydride 
• 89-77-0 2-Amino-4-chlorobenzoic acid 

Downstream Products

• 1427683-41-7 2-amino-4-chloro-N′-(imidazolidin-2-ylidene)benzohydrazide 
• 1609006-91-8 ethyl 5-(2-(3-bromo-1-(3-chloropyridin-2-yl)-1H-pyrazole-5-carboxamido)-4-chlorophenyl)-2,2-dimethyl-1,3,4-oxadiazole-3(2H)-carboxylate 
• 1609006-90-7 methyl 5-(2-(3-bromo-1-(3-chloropyridin-2-yl)-1H-pyrazole-5-carboxamido)-4-chlorophenyl)-2,2-dimethyl-1,3,4-oxadiazole-3(2H)-carboxylate 
• 1609006-78-1 ethyl 5-(2-amino-4-chlorophenyl)-2,2-dimethyl-1,3,4-oxadiazole-3(2H)-carboxylate 
• 1609006-77-0 methyl 5-(2-amino-4-chlorophenyl)-2,2-dimethyl-1,3,4-oxadiazole-3(2H)-carboxylate 
• 1609006-68-9 2-amino-4-chloro-N'-(propan-2-ylidene)benzohydrazide 
• 942265-18-1 5-(2-amino-4-chlorophenyl)-3-(2-furyl)-1H-1,2,4-triazole 
• 93595-53-0 5-(2-Amino-4-chloro-phenyl)-3H-[1,3,4]oxadiazol-2-one 
• 51707-13-2 3-[(2-amino-4-chloro-benzoylhydrazono)-methyl]-rifamycin 

Relevant academic research and scientific papers

ARYL HYDROCARBON RECEPTOR (AHR) ACTIVATOR COMPOUNDS AS CANCER THERAPEUTICS

The present disclosure relates to compositions and methods for the diagnosis and treatment or prevention of cancers, particularly cancers that exhibit elevated expression of FOXA1 and/or FOXA1 gene targets, such as certain breast, liver and/or prostate cancers, including luminal and/or ER-positive forms of breast cancer. Three previously identified adenosine receptor antagonists, CGS-15943, MRS-1220 and SCH-58261, as well as furan ring moiety-possessing derivatives of CGS-15943 are specifically provided for killing cancer cells in a manner that appears to involve activation of the aryl hydrocarbon receptor (AHR) by such compounds. The instant disclosure therefore provides for selecting and/or administering CGS-15943, MRS-1220, SCH-58261 and/or a furan-possessing derivative of CGS-15943, MRS-1220 and/or SCH-58261 as a therapeutic agent to target a cancer cell and/or subject having or at risk of developing a cancer. Methods and compositions for therapies that include such compounds are also provided

Synthesis and insecticidal activity study of novel anthranilic diamides analogs containing a diacylhydrazine bridge as effective Ca2+ modulators

Anthranilic diamides is a class of insecticides target at ryanodine receptors (RyRs). To discover potent insecticides targeting at RyRs, a series of novel anthranilic diamides with a diacylhydrazine bridge were designed and synthesized. Their insecticidal activities were evaluated and a preliminary structure-activity relationship (SAR) was summarized. In particular, compound 5g exhibited good lethality against oriental armyworm (Mythimna separata) at a concentration of 5?mg/L. The calcium imaging experimental results indicated that the compound 5g can serve as effective insect Ca2+ level modulators by disrupting the cellular calcium homeostasis in Mythimna separata (Walker) and Spodoptera exigua (Hübner), which probably activated the RyRs on the ER membrane.

Synthesis and biological activities of 2,3-dihydro-1,3,4-oxadiazole compounds and its derivatives as potential activator of ryanodine receptors

A series of novel 2,3-dihydro-1,3,4-oxadiazoles containing N-pyridylpyrazole carboxamides moieties were obtained by applying a new synthetic route. Their insecticidal tests against oriental armyworm (Mythimna separata) and diamondback moth (Plutella xylostella) indicated that most of the compounds showed moderate to excellent activities at the testing concentrations. In particular, compound 6a showed 40% larvicidal activities against oriental armyworm at 1 mg/L, while 7a against diamondback was 100% at 0.01 mg/L. Calcium imaging results demonstrated that 6a, 6d and 7a stimulated a transient elevation in [Ca2+]i in the absence of external calcium after the central neurons dye loading with fluo-3 AM, implying that these novel compounds were potential activators of the ligand-gated calcium channel on the endoplasmic reticulum.

Synthesis and evaluation of adenosine antagonist activity of a series of [1,2,4]triazolo[1,5-c]quinazolines

A series of [1,2,4]triazolo[1,5-c]quinazolines were prepared in satisfactory yields by reaction of some derivatives of 2-aminobenzohydrazide with several hydrochlorides of aromatic amidines, and their binding affinities for the recombinant human adenosine A2A and A2B receptors were determined. None of the new compounds showed noteworthy affinity for these receptors, though a very high affinity for the A2A receptor and, consequently, a high level of A2A/A2B selectivity was revealed for one of the synthesized compounds.

A diversity oriented synthesis of 2,10-dioxo-10H-1,2,3,4,4a,5-hexahydropyridazino[3,2-b]quinazolines

A parallel method for the synthesis of the title compounds is described. Thus, methyl anthranilates (5) are transformed into 2-aminobenzohydrazides (3) which were treated with 4-oxo acids (4) to afford in high yields and acceptable purity of piridazino[3,2-b]quinazolines (1). Compounds (1) present four diversity centers (R1, R2, R3, and R4). The range of chemically acceptable substituents at each center has been evaluated. The isolation of a possible intermediate in the formation of 1, which presents an amino structure (10), has allowed proposing a complete mechanistic rationalization for the formation of structures (1).