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Guanidine, [3-(1-methyl-5-oxo-2-thioxo-4-imidazolidinyl)propyl]-, also known as 1-Methyl-5-oxo-2-thioxo-4-imidazolidinyl)propylguanidine or MG-132, is a potent and selective proteasome inhibitor. It is a synthetic compound that belongs to the class of guanidine derivatives, which are organic compounds containing the guanidine functional group. MG-132 is widely used in biological research to study the role of the ubiquitin-proteasome system in various cellular processes, such as protein degradation, cell cycle regulation, and apoptosis. By inhibiting the proteasome, MG-132 prevents the degradation of ubiquitinated proteins, leading to their accumulation in cells. This property makes it a valuable tool for investigating the function of specific proteins and understanding the mechanisms underlying various diseases, including cancer and neurodegenerative disorders.

5174-77-6

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Basic information
1. Product Name: Guanidine, [3-(1-methyl-5-oxo-2-thioxo-4-imidazolidinyl)propyl]-
2. Synonyms:
3. CAS NO:5174-77-6
4. Molecular Formula: C8H15N5OS
5. Molecular Weight:
6. EINECS: N/A
7. Product Categories: N/A
8. Mol File: 5174-77-6.mol
Chemical Properties
1. Melting Point: N/A
2. Boiling Point: N/A
3. Flash Point: N/A
4. Appearance: N/A
5. Density: N/A
6. Refractive Index: N/A
7. Storage Temp.: N/A
8. Solubility: N/A
9. CAS DataBase Reference: Guanidine, [3-(1-methyl-5-oxo-2-thioxo-4-imidazolidinyl)propyl]-(CAS DataBase Reference)
10. NIST Chemistry Reference: Guanidine, [3-(1-methyl-5-oxo-2-thioxo-4-imidazolidinyl)propyl]-(5174-77-6)
11. EPA Substance Registry System: Guanidine, [3-(1-methyl-5-oxo-2-thioxo-4-imidazolidinyl)propyl]-(5174-77-6)
Safety Data
1. Hazard Codes: N/A
2. Statements: N/A
3. Safety Statements: N/A
4. WGK Germany:
5. RTECS:
6. HazardClass: N/A
7. PackingGroup: N/A
8. Hazardous Substances Data: 5174-77-6(Hazardous Substances Data)

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Check Digit Verification of cas no

The CAS Registry Mumber 5174-77-6 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 5,1,7 and 4 respectively; the second part has 2 digits, 7 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 5174-77:
(6*5)+(5*1)+(4*7)+(3*4)+(2*7)+(1*7)=96
96 % 10 = 6
So 5174-77-6 is a valid CAS Registry Number.

5174-77-6SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 15, 2017

Revision Date: Aug 15, 2017

1.Identification

1.1 GHS Product identifier

Product name	2-[3-(1-methyl-5-oxo-2-sulfanylideneimidazolidin-4-yl)propyl]guanidine

1.2 Other means of identification

Product number	-
Other names	2-[3-(1-methyl-5-oxo-2-thioxoimidazolidin-4-yl)propyl]guanidine

1.3 Recommended use of the chemical and restrictions on use

Identified uses	For industry use only.
Uses advised against	no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number	-
Service hours	Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

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