5174-94-7

Usage

Explanation

The molecular formula represents the number of atoms of each element present in a molecule. In this case, the compound has 16 carbon (C) atoms, 11 hydrogen (H) atoms, and 3 nitrogen (N) atoms.

Explanation

Organic compounds are chemical compounds that contain carbon and hydrogen atoms. 1,8-Naphthyridin-2-amine, 3-phenyl- falls under this category as it contains both carbon and hydrogen atoms.

Explanation

Aminopyridines are a subclass of organic compounds that consist of a pyridine ring with an amino group (-NH2) attached. 1,8-Naphthyridin-2-amine, 3-phenyl- is a derivative of pyridine with an amino group at position 2.

Explanation

The compound has an amino group (-NH2) at position 2 and a phenyl group (C6H5) at position 3 of the pyridine ring, which makes it a derivative of pyridine.

Explanation

Due to its versatile reactivity and biological activity, 1,8-Naphthyridin-2-amine, 3-phenyl- is commonly used in the synthesis of pharmaceutical drugs and agrochemicals.

Explanation

The compound has potential applications in medicinal chemistry and drug discovery due to its ability to act as a building block for the synthesis of new compounds with therapeutic properties.

Explanation

The compound has a fused structure consisting of a six-membered pyridine ring and a five-membered nitrogen-containing heterocycle (1,8-naphthyridine).

Class

Organic compounds

Subclass

Aminopyridines

Substitution

2-amino and 3-phenyl groups

Applications

Pharmaceutical drugs and agrochemicals

Potential Applications

Medicinal chemistry and drug discovery

Structure

Fused six-membered and five-membered nitrogen-containing heterocycles

Upstream product

• 7521-41-7 2-Aminonicotinaldehyde 
• 140-29-4 phenylacetonitrile 
• 103-81-1 Benzeneacetamide 
• 1196156-67-8 2-amino-6-bromonicotinaldehydev 

Downstream Products

• 5174-92-5 2-hydroxy-3-phenyl-1,8-naphthyridine 
• 1447991-16-3 5′-bromo-3-phenylimidazo[1,2-a][1,8]naphthyridine 
• 1447991-15-2 3-phenylimidazo[1,2-a][1,8]-naphthyridine 
• 5174-92-5 3-phenyl-1,8-naphthyridin-2(1H)-one 
• 1312026-91-7 C₂₂H₂₁N₃O 
• 174651-99-1 N-[1-(4-Nitro-phenyl)-meth-(E)-ylidene]-N'-(3-phenyl-[1,8]naphthyridin-2-yl)-hydrazine 

Relevant academic research and scientific papers

Asymmetric P^N^P type ligand based on 2-aminotetrahydronaphthyridine as well as preparation method of ligand

The invention belongs to the technical field of organic synthesis and discloses an asymmetric P^N^P type ligand based on 2-aminotetrahydronaphthyridine as well as a preparation method of the ligand. The ligand has the structure shown in a formula (I). The

Green Synthesis of Fused Imidazo[1,2-a][1,8]naphthyridine Derivatives Catalyzed by DABCO under Solvent-Free Solid-State Conditions and Their Biological Evaluation

An efficient and eco-friendly methodology has been developed for the construction of fused imidazo[1,2-a][1,8]naphthyridine derivatives in the presence of 1,4-diazabicyclo[2.2.2]octane, and involving various substituted heterocyclic amines with phenacyl b

An Exceedingly Mild, Green Synthesis of Substituted N-3-diaryl-1,8-naphthyridin-2-amine Derivatives and Their Antimicrobial Activity

An exceedingly and highly efficient procedure has been described for the synthesis of substituted N-3-diaryl-1,8-naphthyridin-2-amines by the reaction of 2-chloro-3-aryl-1,8-naphthyridines with various anilines in the presence of N-methyl-2-pyrrolidone and K2CO3 under thermal green solvent-free conditions. The significant features of this green reaction include very good yields in purity, simple experimental, short reaction time, easy workability, and avoidance of toxic solvents. All synthesized compounds have been evaluated for their antibacterial activity.

An Efficient Microwave-Assisted Synthesis of Novel 2-{4-[(3-Aryl-1,8-naphthyridin-2-yl)amino]phenyl}-1H-benzo[de]isoquinoline-1,3(2H)-diones and Their Antimicrobial Activity

The Buchwald–Hartwig amination reaction between 2-chloro-3-aryl-1,8-naphthyridines and 2-(4-aminophenyl)-1H-benzo[de]isoquinoline-1,3(2H)-dione in the presence of the catalytic system Pd(PPh3)4 and the base KO-t-Bu in toluene was studied. The reaction was initiated by microwave irradiation. Highly efficient synthesis has been developed for 2-{4-[(3-aryl-1,8-naphthyridin-2-yl)amino]phenyl}-1H-benzo[de]isoquinoline-1,3(2H)-diones. Structures of the synthesized compounds were evaluated by IR, 1H and 13C NMR spectroscopy. All products were tested for antimicrobial activity against Escheria coli, Bacillus subtilis, Klebsiella pneumoniae, and Staphylococcus aureus.

Naphthyridine-substituted anthracene derivative and organic light-emitting device

The invention provides a naphthyridine-substituted anthracene derivative, having a structure shown as in general formula (I) that is shown in the description, wherein L is selected from a chemical bond, a substituted or non-substituted C6-12 arylene or sub-polycyclic-aromatic group, and substituted or non-substituted C3-12 sub-heteroaryl or sub-condensed-heterocyclic-aromatic group, Ar1 and Ar2 are separately and independently selected from a substituted or non-substituted C6-30 aryl or polycyclic aromatic group and a substituted or non-substituted C3-30 heteroaryl or condensed-heterocyclic-aromatic group, and R1, R2, R3 and R4 are separately and independently selected from hydrogen, C1-10 alkyl, halogen, cyan, nitro, substituted or non-substituted C6-30 aryl or polycyclic aromatic group,and substituted or non-substituted C3-30 heteroaryl or condensed-heterocyclic-aromatic group. The naphthyridine-substituted anthracene derivative has high electron migration rate and good stability and assists in evaporation film-forming when applied to organic light emission.

Cyclometalations on the imidazo[1,2-a][1,8]naphthyridine framework

Cyclometalation on the substituted imidazo[1,2-a][1,8]naphthyridine platform involves either the C3-aryl or C4′-aryl ortho carbon and the imidazo nitrogen N3′. The higher donor strength of the imidazo nitrogen in compariso

Microwave induced Friedlander condensation - A facile synthesis of 1,8-naphthyridines

A simple and efficient method has been developed for the rapid synthesis of 1,8-naphthyridines 3 from 2-aminonicotinaldehyde 1 and active methylene compounds 2 in methanol in the presence of a catalytic amount of piperidine in unmodified domestic microwav

Synthesis of 1,8-naphthyridines under solvent free conditions

Various active methylene compounds 2 reacts efficiently with 2-aminonicotinaldehyde 1 in the presence of piperidine at room temperature within a few minutes and furnish the corresponding 1,8-naphthyridines 3 in high yield under solvent free conditions.

Synthesis of 1,2,4-triazolo[4,3-a] [1,8]naphthyridines

2-Hydroxy-3-phenyl-1,8-naphthyridine (2) on treatment with POCl3 gives 2-chloro-3-phenyl-1,8-naphthyridine (3) which on hydrazinolysis yields 2-hydrazino-3-phenyl-1,8-naphthyridine (4). The hydrazine 4 on condensation with aromatic aldehydes in ethanol containing a catalytic amount of gl. acetic acid affords 3-phenyl-1,8-naphthyridin-2-yl hydrazones (5), which on oxidative cyclization with nitrobenzene under reflux results in the formation of 1-aryl-4-phenyl-1,2,4-triazolo[4,3-a][1,8]naphthyridines (6). Further, 4 when treated with formic acid and gl. acetic acid yields the respective 1,2,4-triazolo[4,3-a][1,8]naphthyridines (7 and 8). The structures of the compounds 3-8 have been established on the basis of their elemental analyses and spectral (IR, 1H NMR and mass) data and are evaluated for their antimicrobial activities.