51741-29-8Relevant academic research and scientific papers
Coordination chemistry of bidentate bis(NHC) ligands with two different NHC donors
Schick, Sabrina,Pape, Tania,Hahn, F. Ekkehardt
, p. 4035 - 4041 (2014)
Reaction of N-aminobenzimidazole 1 or N-aminoimidazole 2 with N,N-bis(dimethyleneamin)azine 3 yielded the biazoles 4-(benzimidazol-1-yl)-4H- [1,2,4]triazole 4 and 4-(imidazol-1-yl)-4H-[1,2,4]triazole 5. Double N,N-alkylation yielded the new bis(NHC) precursors 1-methyl-4-(3- methylbenzimidazol-1-yl)-4H-[1,2,4]triazolium tetraffluoroborate [6a](BF 4)2, 1-ethyl-4-(3-ethylbenzimidazol-1-yl)-4H-[1,2,4] triazolium tetrafluoroborate [6b](BF4)2, and 1-methyl-4-(3-methylimidazol-1-yl)-4H-[1,2,4]triazolium tetrafluoroborate [7](BF4)2, each featuring a triazolium moiety in addition to a benzimidazolium or imidazolium group linked together by a N-N bond. The diazolium salts react with Pd(OAc)2 to give the bis(NHC) complexes [8a](BF4)2, [8b](BF4)2, and [9](BF4)2, each bearing an unsymmetrical triazolylidene/benzimidazolylidene or triazolylidene/imidazolylidene dicarbene ligand coordinated in a chelating fashion to the metal center.
Bicyclic aminoimidazoles
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, (2008/06/13)
The subject invention provides a bicyclic aminoimidazole compound, a hydroxyalkyl aminoimidazole compound, a bicyclic pyrrole compound, a hymenin compound, an aldehyde aminoimidazole compound, a ketal aminoimidazole compound, a tricyclic compound, and a tetrahydropurine compound. The subject invention also provides for processes for preparing the compounds. The bicyclic aminoimidazole compounds of the invention have anti-tumor and anti-microbial activity.
Method for inhibiting advanced glycosylation of proteins using aminosubstituted imidazoles
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, (2008/06/13)
The present invention relates to compositions and methods for inhibiting nonenzymatic cross-linking (protein aging), Accordingly, a composition is disclosed which comprises 2-aminoimidazoles capable of inhibiting the formation of advanced glycosylation endproducts of target proteins by reacting with the carbonyl moiety of the early glycosylation product of such target proteins formed by their initial glycosylation, The method comprises contacting the target protein with the composition, Both industrial and therapeutic applications for the invention are envisioned, as food spoilage and animal protein aging can be treated.
IMIDAZOLE DERIVATIVES CONTAINING POTENTIALLY LABILE GROUPS ON THE N(1) ATOM 8. SYNTHESIS OF N-AMINOIMIDAZOLES VIA 1-AMINO-3-METHOXYMETHYLIMIDAZOLIUM AND 1-AMINO-3-ACETYLIMIDAZOLIUM SALTS
Vinogradova, O. V.,Kryshtalyuk, O. V.,Rudnev, M. I.,Pozharskii, A. F.,Kuz'menko, V. V.
, p. 1182 - 1186 (2007/10/03)
When O-picrylhydroxylamine is reacted with 1-methoxymethyl and 1-acetyl derivatives of imidazole, benzimidazole, 2-cyanomethylbenzimidazole, and perimidine, 1-amino-3-R-imidazolium-, -benzimidazolium, and -perimidinium picrates are formed (R = CH3OCH2, CH3CO).Their subsequent hydrolysis (spontaneous in the case of the N-acetyl derivatives) results in the elimination of the labile R substituent and the formation of the corresponding N-amino-imidazole or -perimidine.In a number of cases this is a more convenient method for their synthesis than the direct amination of NH-heterocycles in alkaline medium.
