51745-26-7

Basic information

• Product Name: 6-benzyloxy-7-methoxy-1-methyl-1,2,3,4-Tetrahydroisoquinoline
• Synonyms: 6-benzyloxy-7-methoxy-1-methyl-1,2,3,4-Tetrahydroisoquinoline;Isoquinoline, 1,2,3,4-tetrahydro-7-Methoxy-1-Methyl-6-(phenylMethoxy)-
• CAS NO: 51745-26-7
• Molecular Formula: C₁₈H₂₁NO₂
• Molecular Weight: 283.36
• Mol File: 51745-26-7.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 423.8°C at 760 mmHg
• Flash Point: 177.6°C
• Appearance: /
• Density: 1.085g/cm³
• Vapor Pressure: 2.17E-07mmHg at 25°C
• Refractive Index: 1.559
• PKA: 9.06±0.40(Predicted)
• CAS DataBase Reference: 6-benzyloxy-7-methoxy-1-methyl-1,2,3,4-Tetrahydroisoquinoline(CAS DataBase Reference)
• NIST Chemistry Reference: 6-benzyloxy-7-methoxy-1-methyl-1,2,3,4-Tetrahydroisoquinoline(51745-26-7)
• EPA Substance Registry System: 6-benzyloxy-7-methoxy-1-methyl-1,2,3,4-Tetrahydroisoquinoline(51745-26-7)

Safety Data

• Hazardous Substances Data: 51745-26-7(Hazardous Substances Data)

Usage

General Description

6-benzyloxy-7-methoxy-1-methyl-1,2,3,4-Tetrahydroisoquinoline is a chemical compound with a complex structure that includes a benzyloxy group, a methoxy group, and a methyl group attached to a tetrahydroisoquinoline backbone. It is commonly used as a starting material for the synthesis of various organic compounds and can also exhibit pharmaceutical properties, particularly in the field of medicinal chemistry. 6-benzyloxy-7-methoxy-1-methyl-1,2,3,4-Tetrahydroisoquinoline has potential applications in drug discovery and development due to its structural features and ability to interact with biological targets, making it an important molecule in the study of neuroactive substances and potential therapeutic agents. Additionally, its unique structure and properties make it a valuable tool for synthetic organic chemists and researchers in the field of medicinal chemistry.

InChI:InChI=1/C18H21NO2/c1-13-16-11-17(20-2)18(10-15(16)8-9-19-13)21-12-14-6-4-3-5-7-14/h3-7,10-11,13,19H,8-9,12H2,1-2H3

Upstream product

• 55161-43-8 N-{2-[3-(benzyloxy)-4-methoxyphenyl]ethyl}acetamide 
• 6857-58-5 6-benzyloxy-7-methoxy-1-methyl-3,4-dihydroisoquinoline 

Downstream Products

• 89-31-6 rac-salsoline 
• 1064202-94-3 6-benzyloxy-7-methoxy-2-(3-methoxybenzyl)-1-methyl-1,2,3,4-tetrahydroisoquinoline 
• 1064203-04-8 (+/-)-7-methoxy-1-methyl-6-sulfamoyloxy-2-(3,4,5-trimethoxybenzyl)-1,2,3,4-tetrahydroisoquinoline 
• 1064203-01-5 (+/-)-2-(3-methoxybenzyl)-7-methoxy-1-methyl-6-sulfamoyloxy-1,2,3,4-tetrahydroisoquinoline 
• 1064202-99-8 (+/-)-6-hydroxy-7-methoxy-1-methyl-2-(3,4,5-trimethoxybenzyl)-1,2,3,4-tetrahydroisoquinoline 
• 1064202-97-6 (+/-)-6-hydroxy-7-methoxy-2-(3-methoxybenzyl)-1-methyl-1,2,3,4-tetrahydroisoquinoline 

Relevant articles and documents

Synthesis, antitubulin, and antiproliferative sar of c3/c1-substituted tetrahydroisoquinolines

The syntheses and antiproliferative activities of novel substituted tetrahydroisoquinoline derivatives and their sulfamates are discussed. Biasing of conformational populations through substitution on the tetrahydroisoquinoline core at C1 and C3 has a pro

Quinolizidines. VIII. Structure and Synthesis of the Alangium Alkaloid Alangicine: Syntheses of (+/-)- and (+)-Alangicines

The first total synthesis of alangicine (3), an Alangium lamarckii alkaloid, has been achieved in the form of a racemic modification by means of an initial alkaline hydrolysis of the (+/-)-tricyclic ester 6 and succeeding steps proceeding through the intermediates (+/-)-7, (+/-)-10, and (+/-)-9.A parallel synthetic route starting with the (-)-tricyclic ester 6, derived from (+)-cincholoipon ethyl ester (8), produced the chiral target molecule (+)-3 via the intermediates (-)-7, (-)-10, and 9.The identity of the synthetic (+)-3 with alangicine unequivocally established the structure and absolute stereochemistry of this alkaloid.The (13)C nuclear magnetic resonance spectra of (+/-)-alangicine (3) and the ipecac and Alangium alkaloid psychotrine (18) confirmed their endocyclic double bond structures in the dihydroisoquinoline moiety.Catalytic reductions of 11, (+/-)-12, and 15 using hydrogen and Pd-C were investigated, and the results have shown that hydrogenolysis of the benzyloxy group proceeds much faster than saturation of the endocyclic C=N bond.Keywords - alangicine; psychotrine; structure; absolute configuration; stereoselective synthesis; (13)C NMR; CD; benzyl ether; hydrogenolysis