51761-93-4

Upstream product

• 186581-53-3 diazomethane 
• 54639-48-4 (6R,7R)-benzhydryl 3-hydroxy-8-oxo-7-(2-phenylacetamido)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate 
• 616-38-6 carbonic acid dimethyl ester 
• 149-73-5 trimethyl orthoformate 
• 54240-49-2 (6R)-3-methylene-8-oxo-7t-(2-phenyl-acetylamino)-(6rH)-5-thia-1-aza-bicyclo[4.2.0]octane-2c-carboxylic acid 
• 51761-91-2 (6R)-7t-amino-3,8-dioxo-(6rH)-5-thia-1-aza-bicyclo[4.2.0]octane-2ξ-carboxylic acid benzhydryl ester; toluene-4-sulfonate 
• 51762-03-9 (6R)-3-methylene-8-oxo-7t-(2-phenyl-acetylamino)-(6rH)-5-thia-1-aza-bicyclo[4.2.0]octane-2c-carboxylic acid benzhydryl ester 
• 859-07-4 cephaloram 
• 51762-07-3 (6R)-3-methoxy-8-oxo-7t-(2-phenyl-acetylamino)-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 

Downstream Products

• 51762-07-3 (6R)-3-methoxy-8-oxo-7t-(2-phenyl-acetylamino)-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 
• 51762-28-8 (6R)-3-methoxy-8-oxo-7t-(2-phenyl-acetylamino)-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid methyl ester 
• 51761-98-9 (6R)-7t-amino-3-methoxy-8-oxo-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester 
• 51762-07-3 (6R)-3-methoxy-8-oxo-7t-(2-phenyl-acetylamino)-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 

Relevant academic research and scientific papers

Novel method for preparing cefroxadine parent nucleus 7-AMOCA

The invention discloses a novel method for preparing a cefroxadine parent nucleus 7-AMOCA. The method comprises the following steps: (1) preparing a methide: adding 3-hydroxycephalosporin, N,N-dimethylformamide and potassium carbonate in the stirring proc

Method for synthesizing parent nucleus of cefroxadine

The invention discloses a method for synthesizing a parent nucleus of cefroxadine. The method includes taking 3-hydroxy-cepham as a starting material, and conducting methylation reaction and removal of an amino-protecting group-phenylacetic group at the 7 position and a protecting group-benzhydryl on the carboxyl at the 4 position sequentially so as to obtain the parent nucleus of the cefroxadine, wherein trimethyl orthoformate serves as a methylation reagent during the methylation reaction. The method has the advantages that the method is simple and safe to implement; during removal of the protecting group on the carboxyl at the 4 position, a scandium trifluoromethanesulfonate catalyst is reusable after being activated, and accordingly environmental protection is benefited; the method is high in product quality and suitable for industrial production. The parent nucleus of the cefroxadine produced by the method is white solid powder with the purity above 99.0%.

N,N'-diisopropyl-O-diphenylmethyl isourea: A mild and convenient alklating agent for the formation of cephalosporin derivatives derivatives

N,N'-Diisopropyl-O-diphenylmethyl isourea reacts with cephalosporin-4- carboxylic acid in tetrahydrofuran at room temperature to give the diphenylmethyl (DPM) ester in good yields without isomerization of the double bond from C-3 to C-2.

Process for the manufacture of 7β-amino-3-cephem-3-ol-4 carboxylic acid compounds

7β-amino-3-cephem-3-ol-4-carboxylic acid compounds of the formula STR1 wherein R1a represents hydrogen or an amino protective group R1A and R1B represents hydrogen or an acyl group Ac, or R1a and R1b together represent a bivalent amino protective group, R2 represents hydroxyl or a radical R2A which together with the carbonyl grouping --C(=O)-- forms a protected carboxyl group and R3 represents hydrogen, lower alkyl or a hydroxyl protective group, and 1-oxides or 3-cephem compounds of the formula IA, and the corresponding 2-cephem compounds are prepared in that a compound of the formula STR2 wherein R1a, R1b and R2A have the meanings mentioned under formula IA, R3o represents lower alkyl or a hydroxyl protective group and Y represents a group which is removed, is treated with a base; also comprised are intermediate products.