51773-76-3

Upstream product

• 33162-63-9 3-endo-aminobornan-2-one 

Downstream Products

• 1925-46-8 (1R)-3endo-methylamino-bornane-2exo-ol 
• 144397-20-6 ((1S,2S,6R)-1,10,10-Trimethyl-3-oxa-5-aza-tricyclo[5.2.1.0^2,6]dec-4-en-4-ylmethyl)-carbamic acid benzyl ester 
• 144397-14-8 Benzyl-((1S,2S,6R)-1,10,10-trimethyl-3-oxa-5-aza-tricyclo[5.2.1.0^2,6]dec-4-en-4-ylmethyl)-amine 
• 144397-23-9 (1S,2S,6R)-1,10,10-Trimethyl-4-phenylselanylmethyl-3-oxa-5-aza-tricyclo[5.2.1.0^2,6]dec-4-ene 
• 144397-21-7 4-Methyl-N-((1S,2S,6R)-1,10,10-trimethyl-3-oxa-5-aza-tricyclo[5.2.1.0^2,6]dec-4-en-4-ylmethyl)-benzenesulfonamide 

Relevant academic research and scientific papers

Preparative scale synthesis of (+) endo-2-hydroxy-endo-3-aminobornane

A convenient preparation of the enantiomerically pure title compound is proposed from (+) camphor in 5 steps with an overall yield between 42 and 62percent.The benzoylation of this compound leads to the expected products 6 and 8 and to the oxazoline 10 formed from 6 with retention of configuration.Key Words: chiral 2-hydroxy-3-aminobornanes / benzoylation / acidic hydrolysis

Stereoselective Reactions. XI. Asymmetric Alkylation of Cyclohexanone via Chiral Chelated Lithioenamines Derived from D-Camphor Derivatives

Metalation and alkylation of the chiral imines prepared from cyclohexanone and methoxy amines (2b, 4c, 6d and 7d) derived from D-camphor derivatives provided, after hydrolysis, optically active 2-alkylcyclohexanones (9) in high enantiomeric purities of up to 99.5percent.Keywords - asymmetric synthesis; asymmetric alkylation; D-camphor; chiral methoxy amine; 2-alkylcyclohexanone; chelated lithioenamine.