51781-14-7

Basic information

• Product Name: 5-(2,3-Epoxypropoxy)-3,4-dihydrocarbostyril
• Synonyms: 5-(2,3-Epoxypropoxy)-3,4-dihydrocarbostyril;3,4-Dihydro-5-(2-oxiranylMethoxy)-2(1H)-quinolinone;Carteolol HCl EP Impurity C;Carteolol Hydrochloride impurity C
• CAS NO: 51781-14-7
• Molecular Formula: C₁₂H₁₃NO₃
• Molecular Weight: 219.23652
• Product Categories: Aromatics;Heterocycles
• Mol File: 51781-14-7.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• Storage Temp.: Refrigerator
• Solubility: Chloroform, Dichloromethane, Methanol
• CAS DataBase Reference: 5-(2,3-Epoxypropoxy)-3,4-dihydrocarbostyril(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(2,3-Epoxypropoxy)-3,4-dihydrocarbostyril(51781-14-7)
• EPA Substance Registry System: 5-(2,3-Epoxypropoxy)-3,4-dihydrocarbostyril(51781-14-7)

Safety Data

• Hazardous Substances Data: 51781-14-7(Hazardous Substances Data)

Usage

Chemical Properties

5-(2,3-Epoxypropoxy)-3,4-dihydrocarbostyril is Off-white Solid

Uses

Different sources of media describe the Uses of 51781-14-7 differently. You can refer to the following data:
1. Used in the preparation of central nervous system depressants. Intermediate in the synthesis of Carteolol (C184450), a β-Adrenergic blocker and an antiarrhythmic agent. Carbostyril derivative.
2. 5-(2,3-Epoxypropoxy)-3,4-dihydrocarbostyril is used in the preparation of central nervous system depressants. Intermediate in the synthesis of Carteolol (C184450), a β-Adrenergic blocker and an antiarrhythmic agent. Carbostyril derivative.

Upstream product

• 30389-33-4 5-hydroxycarbostyril 
• 106-89-8 epichlorohydrin 
• 3132-64-7 1,2-Epoxy-3-bromopropane 

Downstream Products

• 61753-89-7 5-[2-hydroxy-3-(4-carbamyl phenoxyethylamino)]-propoxy-3,4-dihydrocarbostyril 
• 51781-21-6 carteolol hydrochloride 
• 136291-88-8 CART-VI 
• 133154-62-8 6-[4-[2-[3-(3,4-Dihydro-2-hydroxy-quinolin-5-yloxy)-2-hydroxypropylamino]ethoxy]phenyl]-4,5-dihydro-5-methyl-3(2H)-pyridazinone 
• 65006-44-2 5-[2-Hydroxy-3-(3,4-dimethoxy phenethylamino)]-propoxy-3,4-dihydro carbostyril 

Relevant articles and documents

Stable carteolol hydrochloride, preparation method thereof and eye medicine combination

The invention relates to stable carteolol hydrochloride, a preparation method thereof and an eye medicine combination, in particular to a method for preparing carteolol hydrochloride. The method comprises the following steps of preparing 3-amino-2-cyclohexenone, tetrahydro-2,5(1H, 6H)-quinolinone, 5-hydroxy-3,4-dihydro-2(1H)-carbostyril and 5-(2,3-epoxypropoxy)-3,4-dihydro-2(1H)-carbostyril, and then the carteolol hydrochloride is obtained. Furthermore, the invention provides the carteolol hydrochloride crude medicine obtained according to the method, the eye medicine combination prepared by using the obtained carteolol hydrochloride as the crude medicine, and applications of the obtained carteolol hydrochloride to preparation of drugs for treating or preventing glaucoma or ocular hypertension. The method has excellent pharmaceutical characteristics, for example, the obtained crude medicine and a preparation has excellent stability.

Carbostyril compounds connected via an oxyalkyl group with a piperidine ring and having pharmaceutical utility

Carbostyril derivatives of Formula I: STR1 wherein: m is 0, 1, or 2; n is 0, 1, or 2; R1 is hydrogen or lower alkyl; R2 is hydrogen, halogen, hydroxy, lower alkyl, lower alkoxy, aralkoxy, or acyloxy; R3 is hydrogen, halogen, lower alkyl, or lower alkoxy; R4 is hydrogen, hydroxy, lower alkyl, acyloxy, provided that when R4 is hydroxy or acyloxy, m and n are both 1; R5 is hydrogen or lower alkyl; and R6 is alkyl, hydroxyalkyl, alkoxyalkyl, or (dialkylamino)alkyl; and the pharmaceutically acceptable acid addition salts and N-oxides (at the carbostyril nitrogen) thereof, and compositions containing them, are useful in treating cardiovascular diseases, particularly arrhythmias. Methods of preparing intermediates, the compounds, their formulations and methods of treatment therewith are also disclosed.

CARBAMYLPIPERAZINE COMPOUNDS

4-(3-Aryloxy-2-hydroxypropyl)piperazines bearing a carbamyl group in the 1-position are β-adrenergic blockers. A typical example is 1-carbamyl-4-{3-2-allyl-3-(2-carbethoxyaminoethyl)phenoxy!-2-hydroxypropyl} piperazine.