51786-82-4Relevant academic research and scientific papers
Design, Synthesis, and Preclinical Evaluation of 4-Substituted-5-methyl-furo[2,3-d]pyrimidines as Microtubule Targeting Agents That Are Effective against Multidrug Resistant Cancer Cells
Devambatla, Ravi Kumar Vyas,Namjoshi, Ojas A.,Choudhary, Shruti,Hamel, Ernest,Shaffer, Corena V.,Rohena, Cristina C.,Mooberry, Susan L.,Gangjee, Aleem
, p. 5752 - 5765 (2016/07/06)
The design, synthesis, and biological evaluations of eight 4-substituted 5-methyl-furo[2,3-d]pyrimidines are reported. Synthesis involved N4-alkylation of N-aryl-5-methylfuro[2,3-d]pyrimidin-4-amines, obtained from Ullmann coupling of 4-amino-5
BICYCLIC COMPOUNDS HAVING ANTIMITOTIC AND/OR ANTITUMOR ACTIVITY AND METHODS OF USE THEREOF
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Page/Page column 14-15, (2010/02/17)
The present invention provides bicyclic compounds, pharmaceutically acceptable salts, prodrugs, solvates, and hydrates thereof, having antimitotic activity, anti-multidrug resistance activity, such as for example P-glycoprotein inhibition, and antitumor a
