51787-93-0

Basic information

• Product Name: 4,4-Bis-(4-fluorophenyl)-3-ethoxycarbonyl-3-butensaeure
• Synonyms: 4,4-Bis-(4-fluorophenyl)-3-ethoxycarbonyl-3-butensaeure
• CAS NO: 51787-93-0
• Molecular Weight: 346.33
• Mol File: 51787-93-0.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 4,4-Bis-(4-fluorophenyl)-3-ethoxycarbonyl-3-butensaeure(CAS DataBase Reference)
• NIST Chemistry Reference: 4,4-Bis-(4-fluorophenyl)-3-ethoxycarbonyl-3-butensaeure(51787-93-0)
• EPA Substance Registry System: 4,4-Bis-(4-fluorophenyl)-3-ethoxycarbonyl-3-butensaeure(51787-93-0)

Safety Data

• Hazardous Substances Data: 51787-93-0(Hazardous Substances Data)

Upstream product

• 345-92-6 4,4'-Difluorobenzophenone 
• 123-25-1 succinic acid diethyl ester 

Downstream Products

• 149530-27-8 4-(Bis-(4-fluorphenyl)methyl)-3-methylen-4,5-dihydro-2(3H)-furanon 
• 149530-21-2 4-(Bis-(4-fluorphenyl)methyl)-4,5-dihydro-2(3H)-furanon 
• 51787-94-1 2--butandisaeure 
• 51787-97-4 4,4-Bis-(4-fluorophenyl)-butyramid 
• 51787-95-2 4,4-bis(4-fluorophenyl)but-3-enoic acid 

Relevant articles and documents

Inhibition of activated STAT5 in Bcr/Abl expressing leukemia cells with new pimozide derivatives

STATs are transcription factors acting as intracellular signaling after stimulation with cytokines, growth factors and hormones. STAT5 is also constitutively active in many forms of cancers, including chronic myelogenous leukemia, acute lymphoblastic leukemia and Hodgkin's lymphoma. Recently, literature reported that the neuroleptic drug pimozide inhibits STAT5 phosphorylation inducing apoptosis in CML cells. We undertook an investigation from pimozide structure, obtaining simple derivatives with cytotoxic and STAT5-inhibitory activity, two of them markedly more potent than pimozide.