517870-16-5

Basic information

• Product Name: METHYL 5-(4-FLUOROPHENYL)ISOXAZOLE-3-CARBOXYLATE
• Synonyms: METHYL 5-(4-FLUOROPHENYL)ISOXAZOLE-3-CARBOXYLATE;Methyl 5-(4-fluorophenyl)-1,2-oxazole-3-carboxylate
• CAS NO: 517870-16-5
• Molecular Formula: C₁₁H₈FNO₃
• Molecular Weight: 221.18
• Mol File: 517870-16-5.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: METHYL 5-(4-FLUOROPHENYL)ISOXAZOLE-3-CARBOXYLATE(CAS DataBase Reference)
• NIST Chemistry Reference: METHYL 5-(4-FLUOROPHENYL)ISOXAZOLE-3-CARBOXYLATE(517870-16-5)
• EPA Substance Registry System: METHYL 5-(4-FLUOROPHENYL)ISOXAZOLE-3-CARBOXYLATE(517870-16-5)

Safety Data

• Hazard Codes: T
• Statements: 25
• Safety Statements: 45
• Hazardous Substances Data: 517870-16-5(Hazardous Substances Data)

Upstream product

• 403-42-9 1-(4-fluorophenyl)ethanone 

Downstream Products

• 928796-33-2 C₁₀H₇ClFNO 
• 640291-97-0 [5-(4-fluoro-phenyl)-isoxazol-3-yl]-methanol 
• 1416981-52-6 C₃₂H₂₇FN₂O₉ 
• 33282-24-5 5-(4-fluorophenyl)-1,2-oxazole-3-carboxylic acid 

Relevant articles and documents

Design, synthesis and bioactivities of novel isoxazole-containing pyrazole oxime derivatives

In this study, in order to find novel biologically active pyrazole oxime derivatives, twenty-eight new pyrazole oxime compounds containing a substituted isoxazole ring were synthesized and evaluated for their acaricidaland insecticidal activities. Bioassays exhibited that some target compounds indicated good acaricidal and insecticidal activities against Tetranychus cinnabarinus, Aphis medicaginis, Mythimna separata, and Nilaparvata lugens. Especially, compounds 9c, 9h, 9u, and 9v showed 100.00%, 90.56%, 90.78%, and 90.62% insecticidal activities against A. medicaginis at the concentration of 20 μg/mL, respectively, compounds 9k and 9u had 70.86% and 100.00% insecticidal activities against M. separata at 20 μg/mL, respectively.

Synthesis and anticancer activity of heteroaromatic linked 4β-amido podophyllotoxins as apoptotic inducing agents

A series of different heteroaromatic linked 4β-amidopodophyllotoxin conjugates (16a-i, 17a-i and 18a-d) were synthesized and evaluated for anticancer activity against five human cancer cell lines. Among the series, one of the compound 17g showed significant antiproliferative activity in A549 (lung cancer) cell line. Flow cytometric analysis showed that 17g arrested the cell cycle in the G2/M phase leading to caspase-3 dependent apoptotic cell death. Further, Hoechst 33258 staining and DNA fragmentation assay also suggests that 17g induces cell death by apoptosis.