517907-16-3

Upstream product

• 101-92-8 4'-Chloroacetoacetanilide 
• 4637-24-5 N,N-dimethyl-formamide dimethyl acetal 

Downstream Products

• 1088988-04-8 4-bromo-1-(4-chlorophenyl)-2-oxo-1,2-dihydropyridine-3-carbaldehyde 
• 1088987-82-9 4-chloro-1-(4-chlorophenyl)-2-oxo-1,2-dihydropyridine-3-carbaldehyde 
• 1280723-46-7 2-(aminomethylene)-N-(4-chlorophenyl)-3-oxobutanamide 
• 1280723-53-6 3-(4-chlorophenyl)-5-(1-chlorovinyl)pyrimidin-4(3H)-one 
• 1380574-51-5 3-amino-N-(4-chlorophenyl)-2-cyano-6-methylthieno[2,3-b]pyridine-5-carboxamide 
• 1380574-59-3 ethyl 3-amino-5-[(4-chlorophenyl)carbamoyl]-6-methylthieno[2,3-b]pyridine-2-carboxylate 
• 1359047-41-8 N-(4-chlorophenyl)-5-cyano-2-methyl-6-thioxo-1,6-dihydropyridine-3-carboxamide 

Relevant academic research and scientific papers

Tf2O-Mediated Cyclization of α-Acyl-β-(2-aminopyridinyl)acrylamides: Access to N-Substituted 4 H-Pyrido[1,2- a]pyrimidin-4-imines

A facile and efficient direct synthesis of N-substituted 4H-pyrido[1,2-a]pyrimidin-4-imines is developed from α-acyl-β-(2-aminopyridinyl)acrylamides mediated by triflic anhydride (Tf2O) in the presence of 2-chloropyridine. This amide activation

Vilsmeier reaction of enaminones: Efficient synthesis of halogenated pyridin-2(1H)-ones

(Chemical Equation Presented) A facile and efficient one-pot synthesis of halogenated pyridin-2(1H)-ones from a series of readily available enaminones under Vilsmeier conditions is described, and a mechanism involving sequential halogenation, formylation, and intramolecular nucleophilic cyclization is proposed.