51795-96-1

Usage

Uses

Used in Pharmaceutical Industry:
Methanone, cyclopentyl(2-hydroxyphenyl)is used as an intermediate in the synthesis of various pharmaceuticals for its ability to contribute to the development of analgesics and anti-inflammatory drugs. Its unique structure allows it to be a key component in creating effective medications that address pain and inflammation.
Used in Organic Synthesis:
In the field of organic synthesis, Methanone, cyclopentyl(2-hydroxyphenyl)is utilized as a valuable building block for the creation of new compounds and materials. Its cyclopentyl and 2-hydroxyphenyl groups provide a versatile platform for further chemical reactions and modifications, enabling the development of novel molecules with potential applications in various industries.
Used in Medicinal Chemistry:
Methanone, cyclopentyl(2-hydroxyphenyl)plays a significant role in medicinal chemistry, where it is employed in the design and synthesis of new drug candidates. Its unique properties and structural features make it a promising component in the development of innovative therapeutic agents that can address various medical conditions and diseases.
Used in Material Development:
The potential applications of Methanone, cyclopentyl(2-hydroxyphenyl)extend to the development of new materials and compounds. Its unique structure and properties make it a valuable component in the creation of advanced materials with specific characteristics, such as improved stability, reactivity, or selectivity, which can be utilized in various industries, including pharmaceuticals, chemical, and materials science.

Upstream product

• 51821-14-8 o-Hydroxyphenyl-5-brompentylketon 
• 7063-68-5 cyclopentyl(2-methoxyphenyl)methanone 
• 578-57-4 2-bromoanisole 
• 4524-93-0 Cyclopentanecarboxylic acid chloride 
• 3400-45-1 cyclopentanecarboxylic acid 
• 6621-59-6 6-bromo-1-hexanenitrile 
• 88284-48-4 2-(trimethylsilyl)phenyl trifluoromethanesulfonate 
• 287-92-3 Cyclopentane 
• 90-02-8 salicylaldehyde 
• 51795-94-9 5-Brompentyl-o-anisylketon 
• 111-24-0 1,5-dibromo-pentane 
• 1560-11-8 cyclopent-1-enecarboxylic acid 
• 167303-65-3 N-Cyclopentanecarbonyl-N,O-dimethylhydroxylamine 
• 54758-32-6 phenyl cyclopentanecarboxylate 

Downstream Products

• 646522-79-4 trifluoromethanesulfonic acid 2-cyclopentanecarbonylphenyl ester 
• 646522-89-6 2,2-spiropentanylbenzofuran-3-one 

Relevant academic research and scientific papers

The insertion of arynes into the O-H bond of aliphatic carboxylic acids

The insertion of arynes into the O-H bond of aliphatic carboxylic acids promoted by sodium carboxylates is described. The reactions led to the formation of aryl carboxylates in good yields with good chemoselectivities under mild conditions.

Synthesis of Ketones through Microwave Irradiation Promoted Metal-Free Alkylation of Aldehydes by Activation of C(sp3)-H Bond

In this paper, a novel methodology for the synthesis of ketones via microwave irradiation promoted direct alkylation of aldehydes by activation of the inert C(sp3)-H bond has been developed. Notably, the reactions were accomplished under metal-free conditions and used commercially available aldehydes and cycloalkanes as substrates without prefunctionalization. By using this novel method, an alternative synthetic approach toward the key intermediates for the preparation of the pharmaceutically valuable oxaspiroketone derivatives was successfully established.

Intermolecular C-O addition of carboxylic acids to arynes: Synthesis of o-hydroxyaryl ketones, xanthones, 4-chromanones, and flavones

An efficient and simple route to biologically and pharmaceutically important o-hydroxyaryl ketones, xanthones, 4-chromanones, and flavones has been developed utilizing readily available carboxylic acids and commercially available o-(trimethylsilyl)aryl tr

Intermolecular C-O addition of carboxylic acids to arynes

(Figure Presented) A novel, efficient, and expedient route to biologically and pharmaceutically important o-hydroxyaryl ketones, xanthones, 4-chromanones, and flavones has been developed starting from readily available carboxylic acids and commercially available o-(trimethylsilyl)aryl triflates.

Unexpected Migration and Oxidative Cyclization of Substituted 2-Acetophenone Triflates under Basic Conditions: Synthetic and Mechanistic Insights

Oxidative ring closure of alkyl-substituted 2-hydroxyacetophenone trifluoromethanesulfonate esters (triflates) occurs upon exposure to base in anaerobic DMF at 20-90 °C. Alkyl substitution is required for ring closure. A migrated enol triflate product forms at lower temperature in high yield via migration of the trifluoromethanesulfonate in the unsubstituted and monoalkyl-substituted cases. The alkyl-substituted enol triflates also enter into the benzofuran-3-one ring-forming process under thermal cyclization conditions. Potential mechanistic pathways are evaluated.