518-11-6 Usage
Description
One of the colchicine alkaloids, demecolceine has been isolated from the corms
and seeds of Colchicum autumnale, Gloriosa virescens and Littoria modesta. It
forms colourless rods when crystallized from EtOH and has a specific rotation of
[α]D - 223° (CHC13)·
Chemical Properties
Yellow Solid
Uses
An antimitotic agent that disrupts microtubles by binding to tubulin and preventing its polymerization. Stimulates the intrinsic GTPase activity of tubulin. Induces apoptosis in several normal and tumor cell lines and activates the JNK/SAPK signaling pathway.
Check Digit Verification of cas no
The CAS Registry Mumber 518-11-6 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 5,1 and 8 respectively; the second part has 2 digits, 1 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 518-11:
(5*5)+(4*1)+(3*8)+(2*1)+(1*1)=56
56 % 10 = 6
So 518-11-6 is a valid CAS Registry Number.
InChI:InChI=1/C20H23NO5/c1-21-14-7-5-11-9-17(24-2)19(25-3)20(26-4)18(11)12-6-8-15(22)16(23)10-13(12)14/h6,8-10,14,21H,5,7H2,1-4H3,(H,22,23)/t14-/m0/s1
