51802-29-0Relevant academic research and scientific papers
Synthesis and antibacterial evaluation of diaminomaleonitrile-based azo-Schiff bases and 8,9-dihydro-7H-purine-6-carboxamides
Sheykhi-Estalkhjani, Ammar,Mahmoodi, Nosrat O.,Yahyazadeh, Asieh,Pasandideh Nadamani, Meysam
, p. 3835 - 3852 (2020/05/25)
Some new DAMN-based Schiff base 6a–6g were synthesized via a condensation reaction of the corresponding azo dyes with 1-(2-amino-1,2-dicyanovinyl)-3-phenylurea. In continuation, facile synthesis of new 8,9-dihydro-7H-purine-6-carboxamide 7a–7g was reported via an efficient reaction of azo dyes and 1-(2-amino-1,2-dicyanovinyl)-3-phenylurea in the presence of triethylamine as catalyst. All the synthesized compounds were evaluated for their antibacterial activities against both Gram-positive (Micrococcus luteus and Staphylococcus aureus) and Gram-negative (Pseudomonas aeruginosa and Escherichia coli) bacteria.
HETEROARYL COMPOUNDS, COMPOSITIONS THEREOF, AND USE THEREOF AS PROTEIN KINASE INHIBITORS
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Page/Page column 169, (2008/12/05)
Provided herein are Heteroaryl Compounds having the following structure: (I) wherein R1, R2, L, X, Y, Z, Q, A and B are as defined herein, compositions comprising an effective amount of a Heteroaryl Compound and methods for treating or preventing cancer, inflammatory conditions, immunological conditions, metabolic conditions and conditions treatable or preventable by inhibition of a kinase pathway comprising administering an effective amount of a Heteroaryl Compound to a patient in need thereof.
The reactions of diaminomaleonitrile with isocyanates and either aldehydes or ketones revisited
Booth,Dias,Proenca,Zaki
, p. 8436 - 8441 (2007/10/03)
A reinvestigation of the reactions of urea derivatives of diaminomaleonitrile 2 with aldehydes or ketones in the presence of triethylamine has established that the products of these reactions are not pyrimidino[5,4-d]pyrimidines 9 as previously reported, but 8-oxo-6-carboxamido-1,2-dihydropurines 12, which are oxidized rapidly in air to the corresponding 6-carboxamidopurines 13. Similarly, the reaction of Schiff base derivatives of DAMN 5 with isocyanates in the presence of triethylamine gives the substituted 2-oxoimidazoles 20 and not the pyrimidine derivatives 8 as previously claimed. The compounds 20 cyclize in solution and are easily oxidized to 8-oxopurine-6-carbonitriles 22, which give the same 8-oxopurine-6-carboxamides 13 upon further hydrolysis.
