518048-21-0Relevant articles and documents
Dihydroxy-pyrimidine and N-methylpyrimidone HIV-integrase inhibitors: Improving cell based activity by the quaternarization of a chiral center
Nizi, Emanuela,Orsale, Maria Vittoria,Crescenzi, Benedetta,Pescatore, Giovanna,Muraglia, Ester,Alfieri, Anna,Gardelli, Cristina,Spieser, Stephane A.H.,Summa, Vincenzo
scheme or table, p. 4617 - 4621 (2010/04/28)
In the context of HIV-integrase, dihydroxypyrimidine and N-methyl pyrimidone inhibitors the cellular activity of this class of compounds has been optimized by the introduction of a simple methyl substituent in the α-position of the C-2 side chains. Enhanc