51816-48-9

Upstream product

• 79704-02-2 (4-methoxyphenoxy)acetic acid methyl ester 
• 141-43-5 ethanolamine 
• 1877-75-4 2-(4-methoxyphenoxy)acetic acid 
• 104-01-8 4-Methoxyphenylacetic acid 

Downstream Products

• 36214-05-8 6β-[2-(4-methoxy-phenoxy)-acetylamino]-penicillanic acid 
• 1227-61-8 mefexamide 
• 51816-24-1 2-(4-methoxy-phenoxymethyl)-4,5-dihydro-oxazole 
• 2933-77-9 N-(2-hydroxyethyl)-4-methoxyaniline 

Relevant academic research and scientific papers

Silica gel-mediated amide bond formation: An environmentally benign method for liquid-phase synthesis and cytotoxic activities of amides

An efficient, functional group tolerable, and environmentally benign process for the synthesis of amides was developed. No activation reagents or scavengers are required in this process. Purification of desired compounds is easy, rapid, and cost-effective. This protocol provides an alternative for the combinatorial liquid-phase synthesis of amide libraries for drug discovery. By this method, a number of amides were prepared and evaluated in vitro against a panel of human tumor cell lines. Cinnamic amide IV-4 was found to be the most potent compound synthesized against four human tumor cell lines.

Alkoxide-Accelerated Smiles Rearrangements. Synthesis of N-(2-Hydroxyethyl)anilines from N-(2-Hydroxyethyl)(aryloxy)acetamides

The first example of an alkoxide-accelerated Smiles rearrangement is reported.The rearrangement of N-(2-hydroxyethyl)(aryloxy)acetamides in dimethylformamide or tetrahydrofuran-18-crown-6 and potassium hydride produces useful yields of substituted N-(2-hydroxyethyl)anilines.