51827-40-8

Basic information

• Product Name: N-(2-phenylethyl)cyclohexanamine
• Synonyms: N-(2-phenylethyl)cyclohexanamine;UKRORGSYN-BB BBV-130650;N-(2-phenylethyl)cyclohexanamine(SALTDATA: FREE)
• CAS NO: 51827-40-8
• Molecular Formula: C₁₄H₂₁N
• Molecular Weight: 203.32
• Mol File: 51827-40-8.mol
• Article Data: 16

Chemical Properties

• Boiling Point: 315.3°C at 760 mmHg
• Flash Point: 147.7°C
• Appearance: /
• Density: 0.96g/cm³
• Vapor Pressure: 0.000441mmHg at 25°C
• Refractive Index: 1.531
• CAS DataBase Reference: N-(2-phenylethyl)cyclohexanamine(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2-phenylethyl)cyclohexanamine(51827-40-8)
• EPA Substance Registry System: N-(2-phenylethyl)cyclohexanamine(51827-40-8)

Safety Data

• Hazardous Substances Data: 51827-40-8(Hazardous Substances Data)

Usage

InChI:InChI=1/C14H21N/c1-3-7-13(8-4-1)11-12-15-14-9-5-2-6-10-14/h1,3-4,7-8,14-15H,2,5-6,9-12H2

Upstream product

• 64-04-0 phenethylamine 
• 108-95-2 phenol 
• 6125-24-2 2-Phenylnitroethane 
• 626-62-0 Cyclohexyl iodide 
• 121883-35-0 cyclohexylzinc iodide 
• 108-91-8 cyclohexylamine 
• 536-74-3 phenylacetylene 
• 60-12-8 2-phenylethanol 
• 26227-54-3 cyclohexylammonium bromide 
• 103-63-9 1-phenyl-2-bromoethane 
• 126541-72-8 N-cyclohexyl-2-phenylethylamine hydrochloride 
• 110-82-7 cyclohexane 
• 108-94-1 cyclohexanone 
• 128297-83-6 N-(1-benzotriazolyl-methyl)-N-cyclohexyl-amino-ace tonitrile 

Downstream Products

• 126541-72-8 N-cyclohexyl-2-phenylethylamine hydrochloride 
• 1449309-35-6 NTR-N₁A₁B₄ 
• 1449309-43-6 NTR-N₁A₁B₅ 
• 1449309-22-1 NTR-N₁A₂B₁ 

Relevant articles and documents

Rh-PVP Catalyzed Reductive Amination of Phenols by Ammonia or Amines to Cyclohexylamines under Solvent-free Conditions

Colloidal metal nanoparticles were examined for reductive amination of phenol by ammonia under mild reaction conditions. The results showed that Rh-PVP was the most active catalyst for reductive amination reaction. Linear, cyclic, and amino alcohols were used as nucleophiles and converted to primary/secondary/tertiary amines. Using this strategy, the synthesis of an industrially important chemical, N-cyclohexyl- 2-pyrrolidone was explored.

Facile Synthesis and Isolation of Secondary Amines via a Sequential Titanium(IV)-Catalyzed Hydroamination and Palladium-Catalyzed Hydrogenation

An atom economical and catalytic route for the synthesis of aryl- and alkyl-substituted secondary amines has been developed. Using a bis(amidate)bis(amido)titanium(IV) precatalyst, the hydroamination of terminal alkynes with a range of amines results in the selective formation of the anti-Markovnikov product. The crude enamine/imine mixtures are effectively hydrogenated using palladium on carbon (Pd/C) and H2 to afford the corresponding secondary amine in excellent yields. Simple work-up procedures allow for the isolation of pure compounds while avoiding purification via column chromatography.

Selective N-alkylation of primary amines with R-NH2·HBr and alkyl bromides using a competitive deprotonation/protonation strategy

Monoalkylation of primary amines using amine hydrobromides and alkyl bromides has been carried out. Under controlled reaction conditions the reactant primary amine was selectively deprotonated and made available for reaction, while the newly generated secondary amine remained protonated, and did not participate in alkylation further. Reaction was carried out under mild reaction conditions and was applicable to a wide range of primary amines and alkyl bromides.