518308-79-7

Upstream product

• 110-89-4 piperidine 
• 94835-61-7 6-(4-chlorophenyl)-3-cyano-4-methylsulfanyl-2H-pyran-2-one 
• 99-91-2 para-chloroacetophenone 

Downstream Products

• 1030247-01-8 C₂₃H₂₅ClN₂ 
• 1194451-21-2 (E)-3-(2-(4-chlorophenyl)-5,6-dihydro-4H-benzo[kl]acridin-3-yl)-3-(piperidin-1-yl)acrylonitrile 
• 1214891-09-4 C₂₀H₂₁ClN₂O₄ 
• 1236223-54-3 6'-(4-chlorophenyl)-2'-phenyl-3,4,5,6-tetrahydro-2H-[1,4']bipyridinyl-3'-carbonitrile 
• 1632038-85-7 4'-chloro-3-(2-methyl-1,8-naphthyridin-3-yl)-5-(piperidin-1-yl)biphenyl-4-carbonitrile 
• 1632038-90-4 4-(4-chlorophenyl)-2-(piperidin-1-yl)-5,6-dihydronaphtho[2,1-b][1,8]naphthyridine-1-carbonitrile 

Relevant academic research and scientific papers

Substituent-dictated concise synthesis of 4,6-disubstituted N-alkyl-2-pyridones and 2-aminopyridines

Functionalized N-alkyl-2-pyridones and 2-aminopyridines are useful precursors for the synthesis of various heterocyclic compounds of therapeutic importance. In this paper we have delineated and illustrated a direct methodology for the synthesis of 6-aryl-

Ultrasound-assisted synthesis, photophysical behaviour and single crystal X-ray analysis of highly functionalized prenylarenes

A rapid, ultrasound assisted base-catalysed metal free synthesis of a novel series linear prenylarenes 17 incorporated with donor-acceptor functionalities is described via carbanion-induced ring transformation of 4-amino-6-aryl-3-cyano-2H-pyran-2-ones 15 with 6-methylhept-5-en-2-one 16 at room temperature with high yields. Notably, all of the synthesised prenylarenes exhibited blue fluorescence in the 406–468 nm region. The stokes shift, optical band gap, and quantum yield of compounds 17a-17l were computed using their absorption and emission spectra. A significant positive solvatochromic effect was observed, and concentration studies revealed the non-aggregating behaviour of synthesised prenylarenes. Single crystal X-ray diffraction analysis of 17d revealed that crystal belongs to triclinic system with P-1 space group with twisted phenyl rings.

Synthesis, spectral characterization and photophysical studies of tetrahydroquinolines

A metal-free, ultrasound-assisted, fast synthesis of fluorescent N-Boc-protected 1,2,3,4–tetrahydroquinolines 9a-p is described through carbanion-induced ring transformation of 6-aryl-2H-pyran-2-ones 7 with tert?butyl 3-oxopiperidine-1-carboxylate 8 under

Synthesis of Solution-Processable Donor-Acceptor Pyranone Dyads for White Organic Light-Emitting Devices

A series of donor-acceptor pyranones (3a-m, 4a-h) were synthesized using α-oxo-ketene-S,S-acetal as the synthon for their application as emissive materials for energy-saving organic light-emitting devices (OLEDs). Among them, five pyranones 3f, 3g, 3h, 3m

Base-promoted regioselective synthesis of 1,2,3,4-terahydroquinolines and quinolines from N-boc-3-piperidone

An efficient synthesis of 1,2,3,4-tetrahydroquinolines with donor and acceptor group has been delineated by base mediated ring transformation of 6-aryl-4-substituted-2H-pyran-2-one-3-carbonitriles by N-boc-3-piperidone followed by consecutive deprotection

Chemoselective synthesis of m-teraryls through ring transformation of 2 H-pyran-2-ones by 2-(1-arylethylidene)-malononitriles

We have developed a simple, efficient and chemoselective approach for the synthesis of m-teraryls by the reaction of 6-aryl-2-oxo-4-(sec.amino)-2H-pyran-3-carbonitriles and 2-(1-arylethylidene)malononitriles under basic conditions. We used 6-aryl-2-oxo-4-

Microwave directed metal-free regiodivergent synthesis of 1,2-teraryls and study of supramolecular interactions

A microwave directed, simple and efficient synthesis of 3′-amino-5′-(sec.amino)-[1,1′:2′,1′′-teraryl]-4′-carbonitriles has been delineated through ring transformation reaction of 6-aryl-2-oxo-4-sec.amino-2H-pyran-3-carbonitriles by benzyl cyanide under ba

Synthesis, photophysical and anticancer study of D-ring extended estrone analogues

A concise route for the highly substituted ring extended estrone derivatives has been established. This protocol involves very simple, facile and one step ring transformation and cyclization process. The preliminary absorption, emission spectroscopic and

A dual colorimetric-ratiometric fluorescent probe NAP-3 for selective detection and imaging of endogenous labile iron(III) pools in C. elegans

The discovery of an iron(III)-selective ratiometric fluorescent probe to detect and visualize endogenous labile iron pools in living organisms at the molecular level has been long awaited. Herein we report the first dual colorimetric and ratiometric fluor

Base mediated regioselective synthesis of highly functionalized conjugated enones

A simple, regioselective, convenient, and base mediated synthesis of (2E,4E)-5-aryl-6-oxo-6-phenyl-3-sec.amino-hexa-2,4-dienenitriles has been achieved by the reaction of 6-aryl-4-sec.amino-2-oxo-2H-pyran-3-carbonitriles and benzyl cyanide. This reaction