51834-90-3Relevant academic research and scientific papers
Studies of phosphorylation reaction of tertiary amines by NMR spectroscopy
Larina,Rozinov,Komarova
, p. 39 - 46 (2013)
Phosphorylation of tertiary amines containing at least two ethyl groups at the nitrogen atom with phosphorus pentachloride was studied. New C-chlorophosphorylated enamines were characterized by NMR spectroscopy. A scheme was suggested for the phosphorylation reaction. It was found that the presence of two aryl substituents in the molecule of tertiary ethylamine deactivated the ethyl group to block phosphorylation. Phosphorylation of N,N-diethylaniline, besides phenyl-substituted phosphorus-containing enamines, also gave phosphorylated enamines chloro-substituted in the ring. Using N-ethyl-N-methylaniline as an example, a possibility of substitution for two chlorine atoms in the PCl5 molecule with alkenyl groups was demonstrated.
Method for preparing amine compound by reducing amide compound
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Paragraph 0081-0083, (2021/02/10)
The invention relates to a method for preparing an amine compound by reducing an amide compound, which comprises the following steps: in a protective atmosphere, mixing the amide compound or cyclic amide, a zirconium metal catalyst and pinacol borane, carrying out amide reduction reaction at room temperature, and carrying out aftertreatment by using an ether solution of hydrogen chloride after 12-48 hours to obtain an amine hydrochloride compound. The method is simple to operate, low in cost, good in functional group tolerance and wide in substrate range.
Aluminium complex as an efficient catalyst for the chemo-selective reduction of amides to amines
Das, Suman,Karmakar, Himadri,Bhattacharjee, Jayeeta,Panda, Tarun K.
, p. 11978 - 11984 (2019/08/13)
We report an efficient protocol for the catalytic chemo-selective reduction of tert-amides with pinacolborane (HBpin) to afford the corresponding amines in high yields using aluminium complexes [κ2-{Ph2P(X)NC9H6N}Al(Me)2] [X = S (2a), Se (2b)] as pre-catalysts at room temperature. The aluminium complexes were prepared from the reaction of [Ph2P(X)NC9H6N] [X = S (1a), Se (1b)] and trimethylaluminium in toluene. The solid-state structure of complex 2b is established. Tertiary amides with a wide array of electron-withdrawing and electron-donating functional groups were easily converted to the desired products through the selective cleavage of the amides' CO bond by aluminium hydride as an active species. A kinetic study of the catalytic reaction is also reported.
Compounds for the treatment of ischemia
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, (2008/06/13)
A3 agonists having Formula I are described herein as well as methods of using such A3 agonists and pharmaceutical compositions containing such A3 agonists. The A3 agonists are useful for the reduction of tissue
