518343-99-2Relevant articles and documents
Application of the Dakin-West reaction for the synthesis of oxazole-containing dual PPARα/γ agonists
Godfrey, Alexander G.,Brooks, Dawn A.,Hay, Lynne A.,Peters, Mary,McCarthy, James R.,Mitchell, David
, p. 2623 - 2632 (2007/10/03)
An improved method for the preparation of a series of oxazole-containing dual PPARα/γ agonists is described. A synthetic sequence utilizing a Dakin-West reaction was devised that allows for the introduction of the oxazole ring either late in the synthetic sequence via aminomalonate-derived chemistry or in pivotal SAR intermediates derived from aspartic acid.