518357-98-7

Upstream product

• 99186-23-9 2-benzylidenepropane-1,3-diol 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 6626-84-2 dimethyl 2-benzylidenepropanedioate 

Downstream Products

• 518358-00-4 2-[(E)-benzylidene]-3-[(tert-butyl)dimethylsilyloxy]propanal 
• 518357-99-8 2-[(Z)-benzylidene]-3-[(tert-butyl)dimethylsilyloxy]propanal 
• 518358-02-6 methyl (E)-4-{[(tert-butyl)dimethylsilyloxy]methyl}-3-hydroxy-2-methylene-5-phenylpent-4-enoate 
• 518358-01-5 methyl (Z)-4-{[(tert-butyl)dimethylsilyloxy]methyl}-3-hydroxy-2-methylene-5-phenylpent-4-enoate 

Relevant academic research and scientific papers

Synthesis and MMP-inhibitory activity of gelastatin analogues

Gelastatin A and B, isolated from culture broth of Westerdykella multispora F 50733, have been reported to exhibit MMP-inhibitory activities at a sub-micromolar level. In an effort to exploit this lead, we synthesized gelastatin analogues in which the conjugated triene unit of natural gelastatins was replaced by the benzylidene group. The (Z)-isomeric synthetic benzylidene-gelastatin exhibited MMP-inhibitory activities comparable to those reported for the natural products. Therefore, this compound appears to be a viable lead in searching for therapeutically useful MMP inhibitors.