518359-89-2Relevant academic research and scientific papers
Synthesis of some newer indolyl-thiadiazolyl-pyrazolines and indolyl-oxadiazolyl-pyrazolines as potential anti-inflammatory agents
Sharma, Shalabh,Srivastava, Virendra Kishor,Kumar, Ashok
, p. 2647 - 2654 (2007/10/03)
Some new 1-acetyl-5-substitutedaryl-3-[5′-(3″ -indolylmethyl)-2′-amino-1′,3′,4′,-thiadiazol- 2′N-yl]-2-pyrazolines 6a-6e and 1-acetyl-5-substitutedaryl-3-[5′-(3″-indolylmethyl)-2′- amino-1′,3′,4′-oxadiazol-2′N-yl]-2-pyrazolines 6′a-6′e have been synthesized by 5-(3′-indolymethyl)-1,3,4-thiadiazolyl)-2-aminosubstitutedchalkones 5a-5e and 5-(3′-indolylmethyl)-1,3,4-oxadiazolyl-2-aminosubstitutedchalkones 5′a-5′e, respectively. All these compounds of the present series have been screened for their anti-inflammatory activity. Compounds 6c and 6′c are found to be most active compound of this series, which show 47.6% and 49.0% inflammation inhibitory activity at a dose of 50 mg/kg p.o., while standard drug phenylbutazone exhibit 45.6% anti-inflammatory activity at same dose. The structure of these compounds has been illustrated by IR and 1H NMR spectra.
