51865-82-8Relevant articles and documents
Lysine and Ornithine Analogues of Methotrexate as Inhibitors of Dihydrofolate Reductase
Kempton, Robert J.,Black, Angelique M.,Anstead, Gregory M.,Kumar, A. Ashok,Blankenship, Dale T.,Freisheim, James H.
, p. 475 - 477 (2007/10/02)
The ornithine (6a) and lysine (6b) analogues of methotrexate (1) have been synthesized via condensation of 4-amino-4-deoxy-N10-methylpteroic acid (2) with Nδ-carbobenzoxy-L-ornithine tert-butyl ester (3a) and Nε-carbobenzo
Folic acid antagonists. Methotrexate analogs containing spurious amino acids. Dichlorohomofolic acid
Lee,Martinez,Goodman
, p. 326 - 330 (2007/10/06)
The synthesis and some biological testing results are reported for dichlorohomofolic acid (2a) and 3 methotrexate (MTX) analogs in which the L glutamic acid moiety was replaced by D glutamic acid, glutaric acid, and L lysine to give 4b, 4c, and 4d, respec