51884-11-8 Usage
Description
5-(4-Methylphenyl)-4H-1,2,4-triazol-3-amine is a synthetic chemical compound that belongs to the class of organic compounds known as triazoles, which are aromatic rings containing two nitrogen atoms and three carbon atoms. 5-(4-Methylphenyl)-4H-1,2,4-triazol-3-amine is specifically characterized by a 1,2,4-triazole fused with a phenyl ring that carries a methyl substituent. It is primarily used in research and development and can act as a building block in the synthesis of more complex chemical entities. Although there is currently limited information about its toxicity, bioactivity, or commercial use, as a chemical research tool it may demonstrate distinct biological or pharmacological activity.
Uses
Used in Chemical Research and Development:
5-(4-Methylphenyl)-4H-1,2,4-triazol-3-amine is used as a building block for the synthesis of more complex chemical entities, contributing to the advancement of chemical research and the development of new compounds with potential applications in various fields.
Used in Pharmaceutical Industry:
As a chemical research tool, 5-(4-Methylphenyl)-4H-1,2,4-triazol-3-amine may be used in the development of new drugs, potentially demonstrating distinct biological or pharmacological activity that could be harnessed for therapeutic purposes.
Used in Material Science:
5-(4-Methylphenyl)-4H-1,2,4-triazol-3-amine could be employed in the synthesis of new materials with unique properties, such as advanced polymers or composites, for use in various industries, including electronics, automotive, and aerospace.
Check Digit Verification of cas no
The CAS Registry Mumber 51884-11-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,1,8,8 and 4 respectively; the second part has 2 digits, 1 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 51884-11:
(7*5)+(6*1)+(5*8)+(4*8)+(3*4)+(2*1)+(1*1)=128
128 % 10 = 8
So 51884-11-8 is a valid CAS Registry Number.
InChI:InChI=1/C9H10N4/c1-6-2-4-7(5-3-6)8-11-9(10)13-12-8/h2-5H,1H3,(H3,10,11,12,13)
51884-11-8Relevant articles and documents
Diversity-Oriented Synthesis of 1,2,4-Triazols, 1,3,4-Thiadiazols, and 1,3,4-Selenadiazoles from N-Tosylhydrazones
Wei, Zeyang,Zhang, Qi,Tang, Meng,Zhang, Siyu,Zhang, Qian
supporting information, p. 4436 - 4440 (2021/05/26)
The diversity-oriented synthesis of 1,2,4-triazols, 1,3,4-thiadiazols, and 1,3,4-selenadiazoles from N-tosylhydrazones was developed, and the reactions were general for a wide range of substrates, in which NH2CN, KOCN, KSCN, and KSeCN were used as odorless sources. Two different pathways were proposed, and N-tosylhydrazonoyl chlorides were formed in situ in the presence of NCS.
Synthesis and in vitro anti-epileptic activities of novel [1,2,4]-triazolo[1,5-a]pyrimidin-7(4H)-one derivatives
Ding, Jing,Cao, Feng-De,Geng, Yan-Ru,Tian, Yuan,Li, Peng,Li, Xiu-Fen,Huang, Long-Jiang
, p. 1190 - 1204 (2019/01/05)
In this investigation, eight novel 2,5-disubstituted [1,2,4]-triazolo[1,5-a]pyrimidin-7(4H)-one and eight novel 2,5-disubstituted [1,2,4]-triazolo[1,5-a]pyrimidine amine derivatives were synthesized based on the novel marine natural product Essramycin. Their anti-epileptic activities were evaluated by 4-aminopyridine (4-AP)-induced hyper excitability model in primary cultured neocortical neurons. Five compounds with [1,2,4]-triazolo[1,5-a]pyrimidin-7(4H)-one skeleton showed remarkable anti-epileptic activities. The preliminary structure–activity relationship (SAR) showed that the pyrimidine-7(4H)-one motif is the necessary “active core” of anti-epileptic activity. To understand the action mechanism of anti-epileptic activity of [1,2,4]-triazolo[1,5-a]pyrimidin-7(4H)-one compounds, docking studies using the model of GABAA as docking scaffolds were performed and the docking results were in concordance with the experiment observations. (Figure presented.).