519-12-0 Usage
Uses
1. Used in Pharmaceutical Industry:
Setoclavine is used as an active pharmaceutical ingredient for its various biological activities. Its alkaloid nature allows it to form salts with mineral acids, which can be utilized in the development of medications.
2. Used in Research and Development:
Setoclavine's unique properties, such as its optical rotation and ultraviolet spectrum, make it a valuable compound for research purposes. It can be used in the study of ergot alkaloids, their interactions with biopolymers, and their potential applications in medicine.
3. Used in Drug Delivery Systems:
Similar to gallotannin, setoclavine can be incorporated into drug delivery systems to improve its bioavailability and therapeutic outcomes. The development of novel drug delivery systems, such as organic and metallic nanoparticles, can enhance the efficacy of setoclavine in targeted applications.
4. Used in Chemical Synthesis:
Setoclavine's ability to form crystalline salts with mineral acids can be exploited in chemical synthesis for the development of new compounds with potential applications in various industries, including pharmaceuticals, agrochemicals, and materials science.
References
Hofmann et al., Helv. Chim. Acta, 40, 1358 (1957)
Check Digit Verification of cas no
The CAS Registry Mumber 519-12-0 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 5,1 and 9 respectively; the second part has 2 digits, 1 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 519-12:
(5*5)+(4*1)+(3*9)+(2*1)+(1*2)=60
60 % 10 = 0
So 519-12-0 is a valid CAS Registry Number.
519-12-0Relevant articles and documents
New routes to clavine-type ergot alkaloids. Part 1. First total synthesis of three natural products: (+)-setoclavine, (+)-isosetoclavine, (-)-9,10-dihydroisoseto-clavine, and structure correction of the latter
Moldvai, Istvan,Temesvari-Major, Eszter,Gacs-Baitz, Eszter,Incze, Maria,Doernyei, Gabor,Szantay, Csaba
, p. 291 - 298 (2007/10/03)
The double bond in ring D of (+)-9,10-didehydro-6-methylergolin-8-one (2) was reduced selectively by catalytic hydrogenation to yield (-)-6-methylergolin-8-one (6). Grignard reaction of 6 has been performed with methylmagnesium iodide to afford two isomers (5 and 7). The main isomer having an 8α-methyl group at C8 with a C/D-trans junction (5; (-)-dihydroisosetoclavine) proved to be identical with the natural product, hence its name and structure should be corrected. As a minor isomer (7) a C/D-cis clavine derivative was also isolated which can be regarded as unnatural (+)-8α-hydroxycostaclavine. (+)-Setoclavine (8) and (+)-isosetoclavine (9) have also been prepared from 2, thus achieving the first total synthesis of these natural products. Detailed structure elecidation of 5-9 has been carried out as well.
