519157-19-8Relevant articles and documents
PtIV-catalyzed cyclization of arene-alkyne substrates via intramolecular electrophilic hydroarylation
Pastine, Stefan J.,Youn, So Won,Sames, Dalibor
, p. 1055 - 1058 (2007/10/03)
(Figure presented) We herein report that PtCl4 has proven to be a hydroarylation catalyst with an efficiency and substrate scope superior to previously known methods. This catalyst demonstrated consistent performance with arene-yne substrates of diverse structural features, including propargyl ethers, propargylamines, and alkynoate esters, providing good to excellent yields of the 6-endo products (chromenes, dihydroquinolines, and coumarins). In contrast, Pt(II), Pd(II), and Ga(III) salts were shown to be sensitive to the substitution on the alkyne moiety.
