51918-95-7

Usage

Uses

Used in Pharmaceutical Industry:
(4aS,10aS)-2,3,4,4a,10,10a-Hexahydro-8-isopropyl-6,7-dihydroxy-1,1,4a-trimethylphenanthren-9(1H)-one is used as a pharmaceutical agent for its potential hormone-like properties and diverse biological activities. Its complex structure and multiple functional groups may contribute to its efficacy in treating various medical conditions.
Used in Biological Research:
(4aS,10aS)-2,3,4,4a,10,10a-Hexahydro-8-isopropyl-6,7-dihydroxy-1,1,4a-trimethylphenanthren-9(1H)-one is used as a research tool in biological studies to investigate its potential applications and mechanisms of action. Its unique structure and functional groups make it a valuable compound for understanding the interactions between molecules and biological systems.

Upstream product

• 68000-44-2 (4aS,10aS)-8-Isopropyl-6,7-dimethoxy-1,1,4a-trimethyl-2,3,4,4a,10,10a-hexahydro-1H-phenanthren-9-one 
• 128397-99-9 12,13-diacetoxytotara-8,11,13-trien-7-one 
• 51905-93-2 (+/-)-12,13-Dimethoxy-totara-8,11,13-trien 
• 63568-41-2 (+/-)-Dispermol 
• 71596-66-2 2-isopropyl-3,4-dimethoxy-benzoic acid 
• 71596-67-3 3.4-dimethoxy-2-isopropyl-benzoic acid methyl ester 
• 63534-85-0 2-(2-Isopropyl-3,4-dimethoxy-phenyl)-1-(2,6,6-trimethyl-cyclohex-1-enyl)-ethanol 
• 63512-95-8 2-Isopropyl-3,4-dimethoxy-1-[2-(2,6,6-trimethyl-cyclohex-1-enyl)-ethyl]-benzene 
• 63512-92-5 3,4-Dimethoxy-2-isopropylbenzylchlorid 
• 71596-68-4 (2-Isopropyl-3,4-dimethoxy-phenyl)-methanol 
• 63512-96-9 (4aR,10aR)-8-Isopropyl-6,7-dimethoxy-1,1,4a-trimethyl-2,3,4,4a,10,10a-hexahydro-1H-phenanthren-9-one 
• 67979-20-8 (2-Isopropyl-3,4-dimethoxy-benzyl)-triphenyl-phosphonium; chloride 
• 67979-22-0 2-Isopropyl-3,4-dimethoxy-1-[2-((S)-2,6,6-trimethyl-cyclohex-2-enyl)-ethyl]-benzene 
• 67979-21-9 2-Isopropyl-3,4-dimethoxy-1-[(E)-2-((S)-2,6,6-trimethyl-cyclohex-2-enyl)-vinyl]-benzene 

Downstream Products

• 67979-18-4 (4aS,10aS)-6-Benzyloxy-7-hydroxy-8-isopropyl-1,1,4a-trimethyl-2,3,4,4a,10,10a-hexahydro-1H-phenanthren-9-one 
• 51847-85-9 13-methoxytotara-8,11,13-trien-12-ol 
• 67979-19-5 (4aS,10aS)-6-Benzyloxy-8-isopropyl-7-methoxy-1,1,4a-trimethyl-2,3,4,4a,10,10a-hexahydro-1H-phenanthren-9-one 

Relevant academic research and scientific papers

Syntheses and antibacterial activities of diterpene catechol derivatives with abietane, totarane and podocarpane skeletons against methicillin-resistant Staphylococcus aureus and Propionibacterium acnes

Natural catechol, quinone and quinone methide diterpenes with abietane (15-deoxyfuerstione, taxodione) and totarane (dispermone, 12,13-dihydroxy-8,11, 13-totaratriene-6-one), and podocarpane (nimbidiol, deoxynimbidiol) skeletons were synthesized using ortho-oxidation of phenol with meta-chlorobenzoyl peroxide. Minimum inhibitory activities of these diterpenes and previously synthesized natural diterpenes were measured against methicillin-resistant Staphylococcus aureus (MRSA) and Propionibacterium acnes, which cause serious skin infection associated with acne. Abietaquinone methide and 8,11,13-totaratriene-12,13-diol showed potent activities against S. aureus (MRSA) and P. acnes, and no serious toxicity by oral dose to mice.

Investigation of the Structures of Some Natural Products from the Neem Tree

Podocarpic acid (1) and totarol (2) have been converted into five diterpenoids reported to have been isolated from the Neem tree.The synthetic diterpenoids have been compared with the naturally occurring diterpenoids but only the structure of nimbidiol (23) has been confirmed.The structure for margosolone, which was reported as (19), has been revised to (20) after synthesis of both (19) and (20).