5193-03-3

Basic information

• Product Name: 2-CHLORO-6-HYDRAZINOPYRIDINE
• Synonyms: 2-CHLORO-6-HYDRAZINOPYRIDINE;2-CHLOROPYRIDINEHYDRAZINE;6-CHLOROPYRIDIN-2-YLHYDRAZINE;2-Chloro-6-hydrazinylpyridine;(6-Chloro-2-pyridyl)hydrazine, 95%;6-Chloropyridine-2-ylhydrazine
• CAS NO: 5193-03-3
• Molecular Formula: C₅H₆ClN₃
• Molecular Weight: 143.57
• Product Categories: Amines;blocks;Pyridines;Halides;Pyridine;Heterocycle-Pyridine series;amine|alkyl chloride
• Mol File: 5193-03-3.mol
• Article Data: 13

Chemical Properties

• Melting Point: 118°C
• Boiling Point: 118°C
• Flash Point: 117-120°C
• Appearance: /
• Density: 1.418 g/cm³
• Vapor Pressure: 0.002mmHg at 25°C
• Refractive Index: 1.669
• Storage Temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
• PKA: 9.08±0.70(Predicted)
• CAS DataBase Reference: 2-CHLORO-6-HYDRAZINOPYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-CHLORO-6-HYDRAZINOPYRIDINE(5193-03-3)
• EPA Substance Registry System: 2-CHLORO-6-HYDRAZINOPYRIDINE(5193-03-3)

Safety Data

• Hazard Codes: Xi,T
• Statements: 20/21/22-36/37/38-41-25
• Safety Statements: 26-36/37/39-39-45-36
• HazardClass: IRRITANT
• PackingGroup: III
• Hazardous Substances Data: 5193-03-3(Hazardous Substances Data)

Usage

General Description

2-Chloro-6-hydrazinopyridine is a chemical compound with the molecular formula C5H5ClN4. It is a chlorinated pyridine derivative with a hydrazine functional group attached to the sixth carbon atom. 2-Chloro-6-hydrazinopyridine is used in the synthesis of pharmaceuticals and agricultural chemicals due to its ability to act as a versatile building block for various organic transformations. It is also utilized in the preparation of heterocyclic compounds and as a reagent in organic chemistry reactions. Additionally, 2-Chloro-6-hydrazinopyridine has potential applications in the development of new materials and in the field of medicinal chemistry. However, it is important to handle this chemical with caution as it can be hazardous if not properly managed.

Upstream product

• 4774-14-5 2,6-dichloropyrazine 
• 2402-78-0 2,6-dichloropyridine 

Downstream Products

• 1174271-86-3 5-chloro-N-(4-(trifluoromethyl)phenyl)-[1,2,4]triazolo[4,3-a]pyridin-3-amine 

Relevant articles and documents

UREA DERIVATIVES AND USES THEREOF

The present invention provides novel compounds of any one of Formulae (I)-(III), and pharmaceutical compositions thereof. Also provided are particles (e.g., nanoparticles) comprising compounds of Formula (I)-(III) and pharmaceutical compositions thereof that are mucus penetrating. The invention also provides methods and kits for using the inventive compounds, and pharmaceutical compositions thereof, for treating and/or preventing diseases associated with abnormal or pathological angiogenesis and/or aberrant signaling of a growth factor (e.g., vascular endothelial growth factor (VEGF)), such as proliferative diseases (e.g., cancers, benign neoplasms, inflammatory diseases, autoimmune diseases) and ocular diseases (e.g., macular degeneration, glaucoma, diabetic retinopathy, retinoblastoma, edema, uveitis, dry eye, blepharitis, and post-surgical inflammation) in a subject in need thereof.

Triazolo and imidazo dihydropyrazolopyrimidine potassium channel antagonists

Previously disclosed C6 amido and benzimidazole dihydropyrazolopyrimidines were potent and selective blockers of IKur current. Syntheses and SAR for C6 triazolo and imidazo dihydropyrazolopyrimidines series are described. Trifluoromethylcyclohexyl N(1) triazole, compound 51, was identified as a potent and selective Kv1.5 inhibitor with an acceptable PK and liability profile.

Synthesis and studies on the anticonvulsant activity of 5-alkoxy-[1,2,4]triazolo[4,3-a]pyridine derivatives

In this study, a series of new 5-alkoxy-[1,2,4]triazolo[4,3-a]pyridine derivatives was synthesized and their anticonvulsant activity and neurotoxicity was evaluated with the maximal electroshock and rotarod tests, respectively. The most promising compounds, 3p (5-(4-chlorophenoxy)-[1,2,4]triazolo[4,3-a] pyridine) and 3r (5-(4-bromophenoxy)-[1,2,4]triazolo[4,3-a]pyridine), showed a median effective dose of 13.2 and 15.8 mg/kg and had a protective index value of 4.8 and 6.9, respectively. For exploring the putative mechanism of action, compounds 3n, 3p and 3r were tested in chemically induced models. Georg Thieme Verlag KG Stuttgart.New York.