5193-84-0

Usage

Uses

Used in Pharmaceutical Research and Drug Development:
4,6-Dihydroxy-5-methoxypyrimidine is utilized as a key compound in pharmaceutical research and drug development for its potential therapeutic applications. Its antioxidant, anti-inflammatory, and anti-cancer properties make it a promising candidate for the treatment of various diseases and conditions.
Used in Antioxidant Applications:
As an antioxidant, 4,6-Dihydroxy-5-methoxypyrimidine is used to combat oxidative stress and protect cells from damage caused by reactive oxygen species, which can contribute to the development of chronic diseases and aging.
Used in Anti-inflammatory Applications:
In anti-inflammatory applications, 4,6-Dihydroxy-5-methoxypyrimidine is employed to reduce inflammation and alleviate symptoms associated with inflammatory conditions, potentially offering relief in the treatment of arthritis, asthma, and other inflammatory diseases.
Used in Anti-cancer Applications:
4,6-Dihydroxy-5-methoxypyrimidine is used as an anti-cancer agent, where it may inhibit the growth and proliferation of cancer cells, offering a potential therapeutic strategy in oncology.
Used as a Precursor in Synthesis:
In the synthesis of pharmaceutical compounds, 4,6-Dihydroxy-5-methoxypyrimidine serves as a crucial precursor, contributing to the development of new drugs with improved efficacy and reduced side effects.
Used in Chelating Agent and Metal Complex Development:
4,6-Dihydroxy-5-methoxypyrimidine is also used as a chelating agent in the development of metal complexes, which can have applications in various industries, including environmental remediation, catalysis, and material sciences.

InChI:InChI=1/C5H6N2O3/c1-10-3-4(8)6-2-7-5(3)9/h2H,1H3,(H2,6,7,8,9)

Upstream product

• 5018-30-4 dimethyl methoxymalonate 
• 3473-63-0 formamidine acetic acid 

Downstream Products

• 5018-38-2 4,6-dichloro-5-methoxypyrimidine 
• 141071-88-7 4-(5-Methoxy-4-pyrimidinyl)-2-methylpiperazine 
• 141071-86-5 5-methoxy-4-piperazin-1-yl-pyrimidine 

Relevant academic research and scientific papers

INDOLYLALKYL DERIVATIVES OF PYRIMIDINYLPIPERAZINE AND METABOLITES THEREOF FOR TREATMENT OF ANXIETY, DEPRESSION, AND SEXUAL DYSFUNCTION

The present invention relates to a method for alleviation, prevention, and treatment of anxiety, depression, and sexual dysfunction by administering certain indolylalkyl derivatives of pyrimidinylpiperazine or metabolites thereof. A preferred embodiment is of the following formula:

MODULATORS OF METABOLISM AND THE TREATMENT OF DISORDERS RELATED THERETO

The present invention relates to 4-[5-Methoxy-6-(2-methyl-6-[1,2,4]triazol-1-yl-pyridin-3-ylamino)-pyrimidin-4-yloxy]-piperidine-1-carboxylic acid isopropyl ester, pharmaceutically acceptable salts, solvates and hydrates thereof that are modulators of glucose metabolism. Accordingly, compounds of the present invention are useful in the treatment of metabolic-related disorders and complications thereof, such as, diabetes and obesity. (Formula I)

Novel vitronectin receptor antagonist derivatives, method for preparing same, use thereof as medicines and pharmaceutical compositions containing same

A subject of the invention is the compounds of formula (I): in which R1, R2, R3, R4 and G have the meanings indicated in the description, their preparation process, their use as medicaments having an antagonist activity on the vitronectin receptor and the pharmaceutical compositions containing them.

INDOL DERIVATIVES USEFUL FOR THE TREATMENT OF MIGRAINE, COMPOSITION AND UTILIZATION

Indole derivatives having the Formula (I) wherein R1 is H, alkyl or acyl group; R2 is H, halogen or alkyl, hydroxy, alkoxy; ciano, carboxamide, carboxyl, alkoxicarbonyl, phenyl, phenyloxy or a group -(CH2)n-R6, (n=1-3), and R6 is a group ciano, nitro, phenyl, carboxyl, -CO2R7; -CONR7R8; -SO2NR7R8; -COR7; -SO2R7, R7 and R8 being H or alkyl; R7 and R8, together with N, can form a cycle of 4-7 links; R3, R4 and R5 are H, halogen or a group alkyl, phenyl, substituted phenyl, hydroxy, alcoxy, phenyloxy or benziloxy; NR11R12 is H or a group ciano, nitro, carboxyl, alcoxycarbonyl, carboxamido or a group R3; A is an alkyliden group -(CH2)-m, (m = 1-5), or alkenyl group; B is a piperazinoring (a), aminopyrrolidinoring (b); pyrrolidinamino ring (c); piperidinoring (d) or ethylendiamino -NR9-CH2-CH2-NR10-, R9 and R10 being H or an alkyl group. The compounds are useful for the treatment of migraine.

INDOLYLALKYL DERIVATIVES OF PYRIMIDINYLPIPERAZINE FOR TREATING VASCULAR HEADACHE

A series of novel indol-3-ylalkyl derivatives of alkoxypyrimidinylpiperazines are disclosed as Formula I. STR1 These compounds are intended to be useful agents for alleviation of vascular headache on the basis of their potent affinity and agonist activity at 5-HT1D binding sites.

1-indolyalkyl-4-(alkoxypyrimidinyl)piperazines

Certain 1-indolylalkyl-4-(alkoxypyrimidinyl)piperazines of Formula I are useful antidepressant agents. The STR1 substituents R1, R2 and R5 are hydrogen or lower alkyl; R3 and R4 are hydrogen, alkyl, alkoxy, alkythio, carboxamido, halo, or trifluoromethyl; R6 is alkoxy; and n is the integer 2 or 3.