51933-77-8

Basic information

• Product Name: 3-Bromo-2-(methylthio)pyridine
• Synonyms: 3-Bromo-2-(methylthio)pyridine
• CAS NO: 51933-77-8
• Molecular Formula: C₆H₆BrNS
• Molecular Weight: 204.09
• EINECS: 1533716-785-6
• Mol File: 51933-77-8.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 131-132℃ (22 Torr)
• Appearance: /
• Storage Temp.: Room temperature.
• CAS DataBase Reference: 3-Bromo-2-(methylthio)pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Bromo-2-(methylthio)pyridine(51933-77-8)
• EPA Substance Registry System: 3-Bromo-2-(methylthio)pyridine(51933-77-8)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• Hazardous Substances Data: 51933-77-8(Hazardous Substances Data)

Usage

General Description

3-Bromo-2-(methylthio)pyridine is a chemical compound with the molecular formula C6H6BrNS. It is a pyridine derivative with a bromine atom and a methylthio group attached to the second and third carbon atoms, respectively. 3-Bromo-2-(methylthio)pyridine is commonly used as a building block in organic synthesis and medicinal chemistry. It has been studied for its potential biological activities, including its antimicrobial and antifungal properties. Additionally, 3-Bromo-2-(methylthio)pyridine is used as an intermediate in the production of pharmaceuticals, agrochemicals, and other specialty chemicals. It is important to handle this compound with care, as it may pose risks to human health and the environment.

Upstream product

• 626-55-1 3-Bromopyridine 
• 2949-92-0 methanethiosulfonic acid S-methyl ester 
• 52200-48-3 3-bromo-2-chloropyridine 
• 5188-07-8 sodium thiomethoxide 

Downstream Products

• 1448146-94-8 3-[(2-methoxyphenyl)ethynyl]-2-(methylthio)pyridine 
• 1392013-88-5 3-bromo-2-phenylthieno[2,3-b]pyridine 
• 1448146-97-1 3-iodo-2-phenylthieno[2,3-b]pyridine 
• 1448146-98-2 2-(3-fluorophenyl)-3-iodothieno[2,3-b]pyridine 
• 1448146-99-3 2-(4-methoxyphenyl)-3-bromothieno[2,3-b]pyridine 
• 1448147-01-0 2-(2-methoxyphenyl)-3-bromothieno[2,3-b]pyridine 
• 1448146-91-5 2-(methylthio)-3-(phenylethynyl)pyridine 
• 1448146-92-6 3-[(3-fluorophenyl)ethynyl]-2-(methylthio)pyridine 
• 1448146-93-7 3-[(4-methoxyphenyl)ethynyl]-2-(methylthio)pyridine 
• 1644384-77-9 ethyl 4-[3-bromo-2-(methylthio)pyridin-4-yl]benzoate 
• 1393937-14-8 N₁,N₃-bis(2-(methylthio)pyridine-3-yl)benzene-1,3-diamine 

Relevant articles and documents

New in situ trapping metalations of functionalized arenes and heteroarenes with TMPLi in the presence of ZnCl2 and other metal salts

The addition of TMPLi to a mixture of an aromatic or heteroaromatic substrate with a metal salt such as MgCl2, ZnCl2, or CuCN at -78 °C first leads to lithiation of the arene followed by transmetalation with the metal salt to afford functionalized organometallic compounds of Mg, Zn, or Cu. This in situ trapping method allows an expedited metalation (-78 °C, 5 min) of a range of sensitive pyridines (bearing a nitro, ester, or cyano group) and allows the preparation of kinetic regioisomers of functionalized aromatic compounds or heterocycles not otherwise available by standard metalating agents, such as TMPMgCl·LiCl or TMPZnCl·LiCl. Fast, faster, the fastest: Aromatic and heterocyclic substrates, when treated with TMPLi (TMP=2,2,6,6-tetramethylpiperidyl), undergo a kinetic lithiation and then a transmetalation with a metal salt such as MgCl2, ZnCl 2, or CuCN. This allows an expedited metalation of sensitive pyridines bearing a nitro, ester, or cyano group and allows the preparation of kinetic regioisomers of functionalized aromatic compounds or heterocycles.

BENZIMIDAZOLE DERIVATIVES

A compound of formula (I) or a pharmaceutically acceptable salt or prodrug ester thereof: (I) wherein R, X and Y are as disclosed in the specification.