51934-03-3Relevant academic research and scientific papers
Highly Diastereoselective α-Arylation of Cyclic Nitriles
Dalziel, Michael E.,Chen, Penghao,Carrera, Diane E.,Zhang, Haiming,Gosselin, Francis
supporting information, p. 3446 - 3449 (2017/07/15)
A highly diastereoselective α-arylation of cyclic nitriles has been developed via a Negishi cross-coupling of commercially available aryl, heteroaryl, and alkenyl halides with cyclobutyl nitriles in the presence of tetramethylpiperidinylzinc chloride lithium chloride (TMPZnCl-LiCl) and catalytic XPhos-Pd-G2. A variety of electronically diverse electrophiles were well tolerated, and this chemistry was further advanced with application of both cyclopropyl and cyclopentyl nitriles.
