51934-13-5

Upstream product

• 216005-82-2 (1S,2S)-1-(3,4-Dimethoxy-phenyl)-cyclohexane-1,2-diol 
• 216006-01-8 (-)-2-(3,4-dimethoxyphenyl)cyclohex-2-en-1-ol 
• 216005-91-3 Dithiocarbonic acid O-{(1R,2S)-2-(3,4-dimethoxy-phenyl)-2-[2-(methoxycarbonyl-methyl-amino)-ethyl]-cyclohexyl} ester S-methyl ester 
• 216005-94-6 {2-[(R)-1-(3,4-Dimethoxy-phenyl)-3-iodo-4-oxo-cyclohex-2-enyl]-ethyl}-methyl-carbamic acid methyl ester 
• 216005-81-1 3-Chloro-benzoic acid 2-(3,4-dimethoxy-phenyl)-cyclohex-2-enyl ester 
• 216005-92-4 {2-[(R)-1-(3,4-Dimethoxy-phenyl)-cyclohex-2-enyl]-ethyl}-methyl-carbamic acid methyl ester 
• 216005-83-3 2,2-Dimethyl-propionic acid (1S,2S)-2-(3,4-dimethoxy-phenyl)-2-hydroxy-cyclohexyl ester 
• 216006-02-9 2,2-Dimethyl-propionic acid (S)-2-(3,4-dimethoxy-phenyl)-cyclohex-2-enyl ester 
• 216005-87-7 2-[(1S,2S)-1-(3,4-Dimethoxy-phenyl)-2-hydroxy-cyclohexyl]-N-methyl-acetamide 
• 216005-88-8 2-[(S)-1-(3,4-Dimethoxy-phenyl)-2-oxo-cyclohexyl]-N-methyl-acetamide 
• 216005-84-4 4-[(S)-6-(2-Bromo-1-ethoxy-ethoxy)-cyclohex-1-enyl]-1,2-dimethoxy-benzene 
• 216005-85-5 (3aS,7aS)-3a-(3,4-Dimethoxy-phenyl)-2-ethoxy-octahydro-benzofuran 
• 216005-86-6 (3aS,7aS)-3a-(3,4-Dimethoxy-phenyl)-hexahydro-benzofuran-2-one 
• 216005-89-9 (1R,2S)-2-(3,4-Dimethoxy-phenyl)-2-(2-methylamino-ethyl)-cyclohexanol 

Relevant academic research and scientific papers

Asymmetric synthesis of sceletium alkaloids: (-)-Mesembrine, (+)- sceletium a-4, (+)-tortuosamine and (+)-N-formyltortuosamine

Three procedures for the transformation of achiral 1-(3,4- dimethoxyphenyl)cyclohexene into enantiomerically pure 2-(3,4- dimethoxyphenyl)cyclohex-2-en-1-o1 have been established at first. Utilizing the (-)-cyclohexenol thus obtained, the four titled Sceletium alkaloids have been synthesized in the natural enantiomeric forms.