5197-62-6Relevant articles and documents
Smooth receptor ligand
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Paragraph 0085; 0252; 0254; 0263, (2020/04/01)
The invention relates to the technical field of biology, particularly to a smooth receptor ligand, and provides a smooth receptor ligand or an isomer prodrug, a solvate and a pharmaceutically acceptable salt thereof, wherein the structural formula of the smooth receptor ligand is A-linker-B, A is an extracellular domain ligand structure, B is a transmembrane domain ligand structure, and Linker isa linear subunit inactive to the smooth receptor. According to the novel double-end small molecule ligand for the smooth receptor, by combining the crystal structure data of the smooth receptor, a linker is introduced into the proper sites of an extracellular domain ligand and a transmembrane domain ligand to obtain brand-new double-end ligand small molecules, so that the interaction between the ligand and the receptor and the biological activity of the ligand are enhanced.
A 2- chlorine ethoxy group -2-ethoxy-ethanol preparation method (by machine translation)
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Paragraph 0039; 0040, (2017/01/02)
The invention discloses a preparation method of 2-chloroethoxy-2-ethyoxylethanol. The preparation method comprises the steps: with 2-chloroethoxy and ethylene oxide as raw materials, performing a reaction in the presence of a catalyst to firstly obtain 2-ethyoxylethanol, removing the remaining solvent, namely a reactant 2-chlorohydrin, making the 2-ethyoxylethanol continuously react with the re-added ethylene oxide to obtain a target product 2-chloroethoxy-2-ethyoxylethanol. The preparation method has the advantages of being easy to operate during reaction, mild in system, less in side reactions, high in content and yield of products, and less in pollutants generated during the reaction.