5198-79-8

Usage

Uses

Used in Pharmaceutical Industry:
2-Chloro-4-formylthiazole is used as a synthetic intermediate for the development of various pharmaceuticals. Its presence in the molecular structure of certain drugs contributes to their therapeutic effects, making it an essential component in the synthesis process.
Used in Agrochemical Industry:
In the agrochemical sector, 2-Chloro-4-formylthiazole is utilized as a building block in the synthesis of compounds with pesticidal properties. Its incorporation into these molecules can enhance their effectiveness in controlling pests and diseases in agriculture.
Used in Organic Synthesis:
2-Chloro-4-formylthiazole is employed as a versatile intermediate in organic synthesis, allowing for the creation of a wide range of chemical compounds. Its reactivity and structural features make it a valuable asset in the synthesis of complex molecules for various applications.

InChI:InChI=1/C4H2ClNOS/c5-4-6-3(1-7)2-8-4/h1-2H

Upstream product

• 3034-52-4 2-chlorothiazole 
• 2591-86-8 N-Formylpiperidine 
• 68-12-2 N,N-dimethyl-formamide 

Relevant academic research and scientific papers

Method for preparing 2-chloro-1,3-thiazole-5-formaldehyde

The invention discloses a method for preparing 2-chloro-1,3-thiazole-5-formaldehyde. The method comprises the following steps: in the presence of lithium diisopropylamide, carrying out a reaction between 2-chlorothiazole shown in (I) and compounds shown in a formula (II) or compounds shown in a formula (IV) under the condition of low temperature to obtain the 2-chloro-1,3-thiazole-5-formaldehyde shown as a formula (III) (The formula is shown in the specification). In the formula (II), substituent groups R1 and R2 are respectively and separately selected from C1 to C4 alkyls; in the formula (IV), X represents C or O element. According to the method disclosed by the invention, the 2-chloro-1,3-thiazole-5-formaldehyde can be prepared by using the lithium diisopropylamide in wider temperaturerange at higher yield; in addition, the method is not reported in literature; the lithium diisopropylamide has better dehydrogenation selectivity and cannot react with carbonyl.

4-[(4-(CARBOXYETHYL) PIPERIDINYL) METHYL] PYRROLIDINES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY

3-Substituted pyrrolidines having a 4-carboxypiperidinylmethyl substituent on the 4-position of the ring are useful as modulators of chemokine receptor activity. In particular, these compounds are useful as modulators of the chemokine receptors CCR-3 and/or CCR-5.