51985-42-3Relevant academic research and scientific papers
Synthesis and structure-activity relationship study of lamellarin derivatives
Ishibashi, Fumito,Tanabe, Shinji,Oda, Tatsuya,Iwao, Masatomo
, p. 500 - 504 (2007/10/03)
Ten derivatives (3-12) of marine alkaloid lamellarin D (1) were synthesized and evaluated for cytotoxicity against a HeLa cell line in an effort to examine their structure-activity relationships. It appeared that the hydroxyl groups at positions C-8 and C-20 of 1 were important structural requirements for cytotoxic activity, while the hydroxyl group at C-14 and the two methoxy groups at C-13 and C-21 were not necessary for the activity.
Total synthesis and absolute configuration of riccardiphenols A and B, isolated from the Liverwort Riccardia crassa
Tori,Hamaguchi,Sagawa,Sono,Asakawa
, p. 5362 - 5370 (2007/10/03)
The title compounds were synthesized as optically active forms using chiral Michael addition of the imine, prepared from 2-methylcyclohexanone and (S)-(-)-phenylethylamine, to methyl propiolate. The etherification of the intermediate triol was accomplished by TsOH-catalyzed cyclization. The absolute configurations of the natural products, riccardiphenols A and B, were established as 1 and 2, respectively.
