51998-05-1

Usage

Uses

Used in Pharmaceutical Industry:
2-(Isocyanatomethyl)tetrahydrofuran is used as a key intermediate for the synthesis of hydroxamic acid derivatives, which are known for their Gram-negative antibacterial properties. These hydroxamic acid derivatives are particularly effective against bacteria that are resistant to conventional antibiotics, making them a valuable addition to the arsenal of antimicrobial agents.

Upstream product

• 4795-29-3 TETRAHYDROFURFURYLAMINE 
• 24424-99-5 di-tert-butyl dicarbonate 
• 75-44-5 phosgene 

Relevant academic research and scientific papers

[1,2,4 ]TRIAZOLO [1,5-A]PYRIMIDIN-2-YLUREA DERIVATIVE AND USE THEREOF

Novel [1,2,4]triazolo[1,5-a]pyrimidine derivative of the general formula (1): (1) its prodrug or a pharmaceutically acceptable salt thereof, which exhibits an antigen presentation inhibiting activity and is useful as a preventive and/or therapeutic agent for immunological rejection and/or graft versus host reaction in organ/bone marrow transplant, autoimmune disease, allergic disease and/or inflammatory disease and also useful as an anticancer drug or as an immunological tolerance inducer for transplanted organ/transplanted bone marrow.

Organosilicon synthesis of isocyanates: I. Synthesis of isocyanates of the furan, thiophene, and mono-and polyfluorophenyl series

A convenient synthesis of known and unknown isocyanates of the furan, thiophene, and mono-and polyfluorophenyl series, involving silylation of starting amines with hexamethyldisilazane or chlorotrimethylsilane, followed by phosgenation of the resulting N-silyl-substituted amines. An unusual high-temperature rearrangement of 3-(methoxycarbonyl)-4,5-dimethylthiophene-2-yl isocyanate into its 5-ethyl isomer. ortho-Fluorine substituent in anilines decreases the yield of isocyanates, whereas 2,3,5,6-tetrafluorophenyl isocyanate exists for only a short time as a 5% toluene solution. Pleiades Publishing, Inc. 2006.